Adipose Tissue and Cancer by Nikki A. Ford, John DiGiovanni, Stephen D. Hursting (auth.),

By Nikki A. Ford, John DiGiovanni, Stephen D. Hursting (auth.), Mikhail G. Kolonin (eds.)

Recent reports have proven that cells from adipose tissue are able to trafficking to tumors, hence permitting paracrine motion of adipokines from in the tumor microenvironment. elevated tumor vascularization, immune method suppression and direct results on malignant mobilephone survival and proliferation were investigated as mechanisms regulated through adipokines. The objective of this e-book is to debate facts pointing to the position of adipose tissue in melanoma and to dissect person mechanisms in which adipose tissue extra or limit might impression melanoma progression.

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Example text

Consistent with these observations, mortality in patients with certain types of cancer was significantly reduced by gastric bypass surgery [82]. However, in the meta-analysis, IARC did not find the evidence for a lack of significant association of low BMI with reduced risk of CRC in humans. These controversial results indicate that new well-controlled clinical trials on obesity prevention and obesity treatment are necessary before therapeutic implications of WAT reduction on cancer predisposition are completely understood.

Tissue Eng. 2001;7:211–28. 71. Traktuev DO, Merfeld-Clauss S, Li J, Kolonin M, Arap W, Pasqualini R, et al. A population of multipotent CD34-positive adipose stromal cells share pericyte and mesenchymal surface markers, reside in a periendothelial location, and stabilize endothelial networks. Circ Res. 2008;102:77–85. 72. Gimble JM, Guilak F, Nuttall ME, Sathishkumar S, Vidal M, Bunnell BA. In vitro differentiation potential of mesenchymal stem cells. Transfus Med Hemother. 2008;35:228–38. 73. Rehman J, Traktuev D, Li J, Merfeld-Clauss S, Temm-Grove CJ, Bovenkerk JE, et al.

In a mouse tumor model, adiponectin substantially inhibited primary tumor growth in a caspase-dependent manner resulting in endothelial-cell apoptosis [109]. Not all 2 Increased Adiposity and Colorectal Cancer 25 studies revealed an anticarcinogenic effect for adiponectin as observed in adiponectin transgenic mice challenged with the carcinogen azoxymethane and a high-fat diet for 24 weeks [110]. In this study, higher adiponectin levels had no effect on colon tumor incidence, numbers, or size of tumors.

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