Advancements in Tumor Immunotherapy, Cancer Vaccines by H. Arnouk
By H. Arnouk
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Extra info for Advancements in Tumor Immunotherapy, Cancer Vaccines
2010). Overall survival analysis of a phase II randomized controlled trial of a poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer. Journal of Clinical Oncology, Vol. 28, No. 7, (March 2010), pp. , & Kim-Schulze S. (2009). Phase II trial of Modified Vaccinia Ankara (MVA) virus expressing 5T4 and high dose Interleukin-2 (IL-2) in patients with metastatic renal cell carcinoma. , Vol. 7, No. 7:2, (January 2009). , & Vile, R. (2011). Broad antigenic coverage induced by vaccination with virus-based cDNA libraries cures established tumors.
This protein, which is made by several types of cancers including bladder cancer, has been associated with shorter times to development of metastases and reduced survival in bladder cancer. The vaccine in this study is expected to cause the immune system to attack human chorionic gonadotropin- Vaccine and Cancer Therapy for Genitourinary Tumors 31 beta-producing bladder cancer cells to kill or terminate metastasis. This study is expected to conclude in October 2017. 5. Conclusion The key to making vaccine therapy a viable option for the treatment of cancer is in identifying the subject of patients for which a specific vaccine therapy would be most beneficial.
2000). A second study used a hybrid vaccine of allogeneic dendritic cells and irradiated autologous tumor cells in 17 patients with renal cell carcinoma. Patients received the vaccine by injection followed by a second injection six weeks later. Patients who demonstrated no evidence of disease progression received further booster injections every three months. The vaccine was well tolerated with mild to moderate fever and tumor pain as the only adverse events observed. , 2006). Of interest, the dendritic cell hybrid vaccine induced cytotoxic T cells reactive with mucin1 tumor-associated antigen—these results need to be further confirmed in larger, randomized trials.