Advances in Mucosal Immunology: Proceedings of the Fifth by P Brandtzaeg, K Bjerke, T S Halstensen, M Hvatum, K Kett, P

By P Brandtzaeg, K Bjerke, T S Halstensen, M Hvatum, K Kett, P Krajci, D Kvale, F Müller (auth.), Thomas T MacDonald PhD MRCPath, Stephen J Challacombe PhD BDS MRCPath, Paul W Bland PhD, Christopher R Stokes PhD, Richard V Heatley MD MRCP, Allan Mcl Mowat Ph

The immunology of mucosal surfaces is without doubt one of the most enjoyable and appropriate parts of scientific veterinary and dental examine because it applies easy learn to tissues in­ volved in daily defence opposed to microbes and opposed to environmental and nutrients antigens. This booklet is predicated at the contributions provided on the overseas Con­ gress of Mucosal Immunology, held in London in July 1989 and organised by way of the Mu­ cosal Immunology Affinity crew of the British Society for Immunology. The meet­ ing used to be attended by way of over 500 delegates from 27 international locations, together with nearly the entire best investigators within the box. The contents provide complete and up-to­ date details on such themes as antigen presentation and processing within the intestine, mucosal vaccines in guy and animals, HIV an infection within the intestine, the position of yo T cells within the intestine epithelium, fresh advances in inflammatory bowel disorder and coeliac dis­ ease, the function of cytokines within the law of the IgA reaction, mucosal mast cells and cellphone migration. The contributions mirror the speedy velocity of analysis in mucosal immunology, and the nice strides that are happening within the realizing of the immunology, molecular biology and biochemistry of host reaction at mucosal sur­ faces.

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Speculations on the reasons for this difference in processing might include: differences in the molecular structure and antigen-binding capacity of macrophage and enterocyte class II molecules; or an entirely different role for the class II molecule in the two cell types (we have already proposed that the major role of enterocyte class II may be as a recycling antigen receptor, enhancing selective and protected transcytosis of certain antigens during absorption )(Bland, 1988). A third level of antigen processing in the gut - by the class II-bearing macrophage of the lamina propria - was not part of this study.

The antigenic epitope for the T cell receptor for most soluble proteins consists of a short sequence of amino acids and in order for this sequence to bind successfully to the receptor, degradation or conformational changes must take place within the protein molecule. Such processing has been studied in several cell types, including macrophages, dendritic cells and B cells and has been shown to be dependent on energy-dependent mechanisms and on intact lysosomal enzyme systems. 17 Processing of antigens in the gut, however, is a compex, multi-step process involving modification by luminal enzymes in addition to processing steps which can take place in several cell types within the mucosal tissues.

1988) 'Expression of the y-o T-cell receptor on intestinal CD8+ intraepithelial lymphocytes', Nature 333, 855-858. 23. , Nakanishi, N. and Tonegawa, S. (1988) 'Intestinal intraepithelial lymphocytes are a distinct set of y-o T cells', Nature 336, 479-481. 24. , Jones, B. and Hayday, A. (1988) 'SpecifiCity and function of T cells bearing yo receptors', Immunol. Today 9, 73-76. 25. , Brandtzaeg, P. 'Intraepithelial T cells of the TcRylo+CD8- and VollJ ol+ phenotypes are increased in coeliac disease', Scand.

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