Advances in Rapid Sex-Steroid Action: New Challenges and New by Gabriella Castoria, Antimo Migliaccio

By Gabriella Castoria, Antimo Migliaccio

Breast and prostate cancers are either hormone-dependent, at the least in a few levels in their development. Hormonal manipulation represents an immense healing process. even if such a lot of breast and prostate cancers before everything reply to hormone remedy, such a lot tumors reinitiate to development. eventually, hormone-resistant and metastatic breast and prostate cancers may possibly improve. therefore, the problem is the dissection of mechanisms during which steroid receptor signaling pathways proceed to persuade mobile development and invasiveness. Compelling proof exhibits that steroid hormones elicit non-genomic responses in extra-nuclear compartment of objective cells. during this mobile position, steroid-coupled receptors swiftly recruit signaling effectors or scaffold proteins and turn on a number of pathways resulting in proliferation, survival, migration and invasiveness. The speedy problem is the dissection of key occasions regulating the steroid reaction of objective tissues to avoid development and enhance remedy of breast and prostate cancers.

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Additional resources for Advances in Rapid Sex-Steroid Action: New Challenges and New Chances in Breast and Prostate Cancers

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Both ER subtypes bind similarly to EREs, but can differentially regulate genes, particularly via tethered factors; ER-b generally has less transcriptional activity compared to ER-a and has been proposed to act as a brake for ER-a activity, either directly or indirectly [10]. ER function can also be modified by extracellular signals. Growth factors such as EGF and insulin-like growth factor-1 (IGF-1) activate protein kinase pathways leading to phosphorylation and activation of ER and coactivators [12].

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