ALERT • Adverse Late Effects of Cancer Treatment: Volume 2: by Susannah Yovino, Young Kwok (auth.), Philip Rubin, Louis S.

By Susannah Yovino, Young Kwok (auth.), Philip Rubin, Louis S. Constine, Lawrence B. Marks (eds.)

The literature at the past due results of melanoma therapy is greatly scattered in numerous journals due to the fact all significant organ platforms are affected and administration is predicated on quite a few scientific and surgical remedies. the purpose of "ALERT – hostile past due results of melanoma therapy" is to provide a coherent multidisciplinary method of the care of melanoma survivors. quantity 2 of this two-volume paintings comprehensively records strength past due results in the entire common tissue anatomic websites within the human physique. The detection, analysis, administration and prevention of results are all thought of intimately, and prognostic results are mentioned. Radiation probability elements and interactions with chemotherapy results are in actual fact offered. The textual content is observed by means of various supportive illustrations and tables. it really is expected that this textbook becomes the foremost in offering details at the past due results of melanoma therapy and that, in its digitized shape, will probably be referenced in melanoma survivorship guidelines.

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2003). 1 Other Cranial Nerves The olfactory optic nerves are similar to CNS brain tissue in radiation sensitivity. The data presented above regarding the tolerance of the optic nerve cannot be extrapolated to the remainder of the cranial nerves. The majority of cranial nerves are similar to peripheral nerves as to their radiosensitivity. Cranial nerves within the cavernous sinus appear to be radioresistant and have been reported to tolerate single-fraction doses of up to 40 Gy (Tishler et al. 1993).

2007). Magnetic resonance spectroscopy is able to differentiate between the molecular resonance frequencies of different constituents of the CNS, although its spatial resolution is poor. CNS lesions Brain and Cranial Nerves Fig. 10 Relationship between volume receiving high-dose irradiation and incidence of radiation necrosis in single-fraction stereotactic radiosurgery. Studies differed in their completeness of follow-up, definition of volume, and definition of radiation necrosis. Volume plotted as a point, representing mid-point of volume range.

The tolerance (\1 % risk) of the optic nerve at single fraction radiosurgery doses appears to be 8–10 Gy provided that the patient does not have a history of external radiation (Tishler et al. 1993; Stafford et al. 2003). 1 Other Cranial Nerves The olfactory optic nerves are similar to CNS brain tissue in radiation sensitivity. The data presented above regarding the tolerance of the optic nerve cannot be extrapolated to the remainder of the cranial nerves. The majority of cranial nerves are similar to peripheral nerves as to their radiosensitivity.

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