Alkaline Phosphatase by Robert B. McComb

By Robert B. McComb

There might be without doubt that alkaline phosphatase is without doubt one of the such a lot greatly in­ vestigated of all enzymes. This has resulted from the ubiquity of its distribution, and from the benefit and sensitivity with which its task could be measured. regrettably, those wide-ranging yet frequently superficial experimental stories were up through in depth and systematic investigations in just a number of constrained parts of the biochemistry and chemical pathology of alkaline phosphatase. the end result has been the buildup of a systematic literature of intimidating proportions, and the inevitable rediscovery of already­ recognized proof concerning the enzyme. Scientists are taught early of their careers that, within the phrases of Sir John Herschel, "Hasty generalization is the bane of technology. " however, moments arrive in all spheres of clinical task whilst generalization turns into crucial, to codify and to choose from the mass of knowledge already gathered, and to supply beginning issues for brand new advancements and new strains of research. this is often very true in a box akin to alkaline phosphatase examine, within which very actual risks exist that the seeds of basic knowing might be misplaced amidst an unexamined harvest of empirical observations. The historical past of the research of alkaline phosphatase offers numerous cases while beneficial generalizations have emerged. sometimes, the conclusions drawn at the foundation of obtainable facts have been mistaken; extra often, they've got stood the try of additional experimentation, and regularly, they've got supplied new insights into the character and correct­ ties of this enzyme.

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139. Du Bois, K. , Cochran, K. , Inhibition of phosphatases by beryllium and antagonism of the inhibition by manganese, Science, 11 0,420, 1949. 140. Fishman, W. , Organ-specific behavior exhibited by rat intestine and liver alkaline phosphatase, Biochirn. Biophys. Acta, 62, 363, 1962. 141. , Kinetics and inhibition of alkaline phosphatases from canine tissues, Biochirn. Biophys. Acta, 289,158,1972. 142. Shinowara, G. , and Reinhart, H. , The estimation of serum inorganic phosphate and "acid" and "alkaline" phosphatase activity, I.

HISTORICAL BACKGROUND 23 179. Carr, J. , and Foote, F. , Alkaline and acid phosphatase levels in the serum of dogs after ligation of the common bile duct,Arch. Surg. (Chicago), 49,44,1944. 180. , The influence of icteric sera with high phosphatase activity on the phosphatase activity of normal sera,Am. J. Clin. , ZO, 858, 1940. 181. , Les phosphatases du sang dans Ie diagnostic des affections osseuses, J. , 33, 213, 1934. 182. , La phosphatase serique pendant la gestation, C. R. Seances Soc. BioI.

225. Robinson, J. , and Pierce, J. , Differential action of neuramidase on human serum alkaline phosphatase, Nature (London), 204,472, 1964. 226. , Production of antibodies against dog intestinal phosphatase, J. Bioi. , 206, 361, 1954. 227. , Specificity of dog intestinal phosphatase antiserum, J. Bioi. ,206, 369, 1954. 228. Lehmann, F. , Immunological relationship between human placental and intestinal alkaline phosphatase, Qin. Chim. Acta, 65, 257,1975. 229. , Alkaline phosphatase, Ann. Intern.

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