Analysis of Genes and Genomes by Richard J. Reece

By Richard J. Reece

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Reproduced from Jacob and Monod (1961). Model II depicts a microRNA-like mechanism. Both models were proposed for the lac repressor and turned out to be false, as the lac repressor is a protein transcription factor. However, model I and II may underlie short RNA mediated gene regulation at the transcriptional and posttranscriptional level respectively. general model a number of factors have been directly implicated in microRNA function in C. elegans. , 2004). , 2001; Knight and Bass, 2001). Interestingly, two Argonaute family members, Alg-1 and Alg-2 are also required for the generation of the mature microRNA from pre-miRNA, suggesting that at least in C.

The microRNAs world did not take off until the discovery of RNAi, and let-7, a second microRNA discovered by Ruvkun and his colleagues in 2000. The highly conserved nature of let-7 attracted a great deal of attention to microRNAs research and since then many groups have identified microRNAs in various organisms, from protozoans to humans. The paradigm from the heterochromic lin-4/lin-14 genes remains the model; miRNAs have now been shown to control mRNA abundance in plants, and are thought to regulate many more steps beyond translation.

2000). Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature, 408, 86–89. The microRNAs of C. elegans Pillai, R. , Bhattacharyya, S. , Artus, C. G. et al. (2005). Inhibition of translational initiation by let-7 microRNA in human cells. Science, 309, 1573–1576. Rajewsky, N. and Socci, N. D. (2004). Computational identification of microRNA targets. Developmental Biology, 267, 529–535. Reinhart, B. , Slack, F. , Basson, M. et al. (2000). The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans.

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