Animal cell technology: from biopharmaceuticals to gene by Leda R. Castilho

By Leda R. Castilho

Advent to animal phone expertise /, Animal cells: easy strategies /, Cloning and expression of heterologous proteins in animal cells /, phone metabolism and its keep an eye on in tradition /, tradition media for animal cells /, Post-translational amendment of recombinant proteins /, Mechanisms of mobilephone proliferation and cellphone dying in animal mobilephone tradition in vitro /, Mathematical versions for development and product synthesis in animal telephone tradition /, Bioreactors for animal cells /, tracking and regulate of mobilephone cultures /, Animal phone separation /, Product purification techniques /, qc of biotechnological items /, Regulatory features /, highbrow estate /, Recombinant healing proteins /, Monoclonal antibodies /, Viral vaccines: suggestions, rules, and bioprocesses /, Bioinsecticides /, mobile treatments and stem cells /, Gene treatment /; Paula Marques Alves, Manuel Jose Teixeira Carrondo, & Pedro Estilita Cruz --, Patricia Leo ... [et al.] --, Mariela Bollati-Fogolin & Marcelo A. Comini --, Paola Amable & Michael Butler --, Angela Maria Moraes, Ronaldo Zucatelli Mendonca, & Claudio Alberto Torres Suazo --, Michael Butler --, Maira Peixoto Pellegrini, Rodrigo Coelho Ventura Pinto, & Leda dos Reis Castilho --, Elisabeth F.P. Augusto, Manuel F. Barral, & Rosane A.M. Piccoli --, Ernesto Chico Veliz, Gryssell Rodriguez, & Alvio Figueredo Cardero --, Aldo Tonso --, Leda dos Reis Castilho & Ricardo de Andrade Medronho --, Angela Maria Moraes, Leda Castilho, & Sonia Maria Alves Bueno --, Marina Etcheverrigaray & Ricardo Kratje --, Maria Teresa Alves Rodrigues & Ana Maria Moro --, Ana Cristina Almeida Muller & Leila Costa Duarte Longa --, Maria Candida Maia Mellado & Leda dos Reis Castilho --, Wirla M.S.C. Tamashiro & Elisabeth F.P. Augusto --, Isabel Maria Vicente Guedes de Carvalho Mello ... [et al.] --, Marcia Regina da Silva Pedrini & Ronaldo Zucatelli Mendonca --, Hamilton da Silva Jr. & Radovan Borojevic --, Celio Lopes Silva ... [et al.]

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Extra resources for Animal cell technology: from biopharmaceuticals to gene therapy

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By the use of the hanging drop technique and frog heart lymph, Ross Harrison, at Yale, tried between 1906 and 1910 to elucidate how the nervous fiber is originated (Witkowski, 1979). He considered three hypotheses: (i) in situ formation from the nerve sheath; (ii) preformed protoplasmic bridges; or (iii) as a result of the nerve cell growth itself. When Harrison demonstrated the validity of the third hypothesis, he also confirmed the cell as the primary developing unit of multicellular organisms.

Rev. , Suppl. Vol. 3. Hwang WS, Ryu YJ, Park JH, Park ES, Lee E, Koo, JM, Jeon HY, Lee BC, Kang SK, Kim SJ, Ahn C, Hwang JH, Park KY, Cibelli JB, Moon SY (2004), Evidence of a pluripotent human embryonic stem cell line derived from a cloned blastocyst, Science 303:1669–1674. Kohler G, Milstein C (1975), Continuous cultures of fused cells secreting antibody of predefined specificity, Nature 256:495–497. Laflamme MA, Murry CE (2005), Regenerating the heart, Nat. Biotechnol. 23: 845–856. Land H, Parada LF, Weinberg RA (1983), Tumorigenic conversion of primary fibroblasts requires at least two co-operating oncogenes, Nature 304:596–602.

Vero cells (a cell line derived from monkey) were used for anti-rabies vaccine. Hybridomas were considered acceptable for mAb production and the use of genetically modified CHO (Chinese hamster ovary) cells was authorized for the production of tissue plasminogen activator (tPA) by Genentech in 1986. Finally, three relevant aspects should be mentioned to clarify the scientific, technological, and industrial position of biopharmaceuticals and animal cells. (i) Complex biopharmaceuticals, such as proteins, virus or virus-like particles (VLPs), among others, produced by cellular and/or recombinant technologies are characterized/defined by their own production processes.

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