Application of Hyperthermia in the Treatment of Cancer by S. B. Field (auth.), Dr. med. Dipl. biochem. Rolf D. Issels,

By S. B. Field (auth.), Dr. med. Dipl. biochem. Rolf D. Issels, Prof. Dr. med. Wolfgang Wilmanns (eds.)

Physicians, biologists and physicists current their contemporary paintings within the box of hyperthermia in regards to either its software and its mix with radiation and chemotherapy. present technical chances, medical administration and significant features of its use for superficial and deep-seated tumors are mentioned. the most subject matters mentioned are: adjustments of metabolism and microcirculation lower than warmth stipulations, the organic interplay of warmth with X-rays and a number of other chemotherapeutic brokers, and the newest scientific information from diversified associations at the mixed software within the therapy of cancer.

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Discussion As shown by previous studies (Kreisl and Lengfelder 1984; Betts et al. 1983; Fink and Lengfelder 1987) degradation of HA is an appropriate parameter to investigate the production and reactivity of OR" -like species as well as the formation of ferryl (Fe2+0) and/or perferryl (Fe2+02 ~ FeHOn species. Our present results demonstrate that the potential of various thiols in promoting the generation of highly oxidizing species in the presence of chelated ferric ions greatly depends on the type and effective concentration of thiol applied, as well as on the prevailing temperature.

Taylor and Francis, London, pp 173-176 Lammertsma AA, Wise RJS, Cos TCS, Thomas DGT, Jones T (1985) Measurement of blood flow, oxygen utilisation, oxygen extraction ratio, and fractional blood volume in human brain tumours and surrounding oedematous tissue. Br J Radiol 58: 725 - 734 Lee SY, Song CW, Levitt SH (1985) Change in fibrinogen uptake in tumors by hyperthermia. Eur J Cancer Clin Oncol12: 1507-1513 Lee SY, Ryu K, Kang MS, Song CW (1986) Effect of hyperthermia on the lactic acid and fJ-hydroxybutyric acid contect in tumor.

In this instance the circulation was evaluated by means of a laser-doppler fluxmeter, giving an indication of the total erythrocyte flux in the tumour. As can be seen (in Fig. 2, when the temperature is increased, the tumour blood flow first increases, then maintains a plateau for some time but, under the conditions of the continuous temperature increase, the flow index again starts to rise. Then, at a given heat dose, the circulation collapses, and even when the temperature is not increased further a complete vascular stasis develops.

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