Bacterial Signal Transduction: Networks and Drug Targets by Yoko Eguchi, Ryutaro Utsumi (auth.), Ryutaro Utsumi PhD

By Yoko Eguchi, Ryutaro Utsumi (auth.), Ryutaro Utsumi PhD (eds.)

This attention-grabbing booklet encourages many microbiologists and scholars to go into the hot global of sign transduction in microbiology. during the last decade, an unlimited quantity of intriguing new details at the sign transduction pathway in micro organism has been dropped at mild. studies on those advancements were prepare during this booklet, Bacterial sign Transduction: Networks and Drug goals. the purpose of this publication is to supply an incentive for graduate scholars, educational scientists, and researchers within the pharmaceutical to extra elucidate the TCS networks and follow them within the look for novel drugs.

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7C). From Dimerization Domain to RR TrrA molecule binds to the His-containing helix-I in the dimerization domain (Fig. 9A). The similar situation could be observed in SpoOB system. 27 A ofthe distance in the their complex. In the intermediate ofthe phosphoryl transfer reaction from His of the HK dimerization domain to Asp of the RR receiver domain, a penta-coordinared phosphorous atom could be formed by binding to both proteins/" Two RRs bind separately to form the HK/RR complex (Fig. 9). Therefore, RRs form its homodimer after accepting a phosphoryl group and dissociation from HK for transcriptional activation.

Mg" as an extracellular signal: environmental regulation of Salmonella virulence. Cell 1996; 84:165-174. 20. Chamnongpol S. Cromie M. Groisman EA. Mg" sensing by the Mg>+ sensor PhoQ of Salmonella enterica. J Mol Bioi 2003; 325:795-807. 21. Garda Vt'scovi E, Ayala M, Di Cera E et al. Characterization of the bacterial sensor protein PhoQ Evidence for distinct binding sites for Mg>+ and Ca 2+. J Mol Bioi 1997; 272:1440-1443. 22. Cho US. Bader MW; Amaya MF et al. Metal bridges between the PhoQ sensor domain and the membrane regulate transmembrane signaling.

The PmrA-regulated pmrC gene mediates phosphoethanolamine modification of lipid A and polymyxin resistance in Salmonella enterica. J Bacteriol 2004; 186:4124-4133. 76. Tamayo R, Choudhury B, Septer A et al. Identification of cptA, a PmrA-regulated locus required for phosphoethanolamine modification of the Salmonella enterica serovar typhimurium lipopolysaccharide core. J Bacteriol 2005; 187:3391-3399. 77. Delgado MA, Mouslim C, Groisman EA. The PmrA/PmrB and RcsC/YojN/RcsB systems control expression of the Salmonella O-antigen chain length determinant.

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