Behavioral Genetics in the Postgenomic Era by Robert Plomin, John C. Defries, Ian W. Craig, Peter McGuffin

By Robert Plomin, John C. Defries, Ian W. Craig, Peter McGuffin

The second one writer is with the Univ. of Colorado, Boulder. offers a dialogue of genetic examine on habit and specializes in cognitive talents, character, psychopathology, and psychopharmacology. Written for psychology, psychiatry, behavioral, biomedical, and organic sciences pros.

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Et al. (1999). DNA pooling identifies QTLs on chromosome 4 for general cognitive ability in children. Human Molecular Genetics, 8, 915-922. , Holland, M. , & Higuchi, R. (2000). High-throughput SNP allele-frequency determination in pooled DNA samples by kinetic PCR. Genome Research, 10, 258-266. , Craig, I. , e t al. DNApooling and dense marker maps: A systematic search for genes for cognitive ability. Neuroreport, 10, 843-848. , Hamshere, M. , et al. (2000). Cheap, accurate and rapid allele frequency estimation of single nucleotide polymorphisms by primer extension and DHPLC in DNA pools.

Recently, this approach has been modified such that both allele-specificprimers are combined in a single competition reaction (Craig, McClay, Plomin, & Freeman, 2000; McClay, Sugden, Koch, Higuchi, & Craig, 2002). 5). Allele-specific primers can also be adapted for use in real-time, or “kinetic,” PCR-particularly in the context of analyzing pooled DNA samples (Germer, Holland, & Higuchi, 2000). 4. Primer extension methodology using chain termination to detect single nucleotide polymorphisms (SNPs).

Thousands of genotypes on a single chip. New developments should soon enable chip technology t o be applied t o pooled DNA samples, thereby conferring the advantages of both multiple genotyping and high sample throughput. Other Strategies for Size Fractionating Alleles Generated by SNPs: M . 8. Single nucleotide polymorphism (SNP) detection via the “Invader” assay. In the primary reaction, two probes bind t o the target DNA, only if the sequence matches precisely that of the allele being followed will the ‘%ap”of the detection probe be displaced and cleaved.

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