Bipolar Depression: Molecular Neurobiology, Clinical by Carlos A. Zarate Jr., Husseini K. Manji

By Carlos A. Zarate Jr., Husseini K. Manji

Even supposing our wisdom of temper problems typically is increasing progressively, relatively little is understood approximately bipolar melancholy particularly. This ebook brings jointly best clinicians and preclinical and scientific researchers to supply the main updated information regarding the analysis, remedy, and examine surrounding bipolar melancholy. Early chapters supply useful diagnostic info, and assessment the direction, end result, and genetics of this hugely heritable situation, permitting clinicians to tell apart among a number of the temper problems. The booklet bargains a radical and distinctive evaluation of the neurobiology of the affliction, together with what's recognized from contemporary neuroimaging paintings. numerous chapters delineate the therapy of bipolar melancholy in distinct populations comparable to kids and pregnant ladies, and one other bankruptcy addresses the actual problems with suicide, concentrating on the necessity for review in the course of either acute and upkeep remedy with interventions applicable to a patient's indicators and heritage. eventually, the e-book covers acute and long term remedy suggestions for bipolar melancholy, together with either conventional and novel therapeutics for the affliction, in addition to non-pharmacological remedies. This publication has assembled a greatly revered workforce of preclinical and medical researchers who deliver their services to endure upon this affliction. It bargains researchers, clinicians, and postgraduate scholars key insights into this devastating disease.

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Extra resources for Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis and Pharmacotherapy (Milestones in Drug Therapy)

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Predictors of manic recurrence were initial mood-incongruent psychotic features, lower premorbid occupational status, and initial manic presentation. Predictors of depression onset were higher occupational status, initial mixed presentation, and any comorbidity [24]. Targeting residual symptoms in maintenance treatment may represent an opportunity to reduce risk of recurrence of bipolar disorder. Another 2-year follow-up study of the clinical features associated with the risk of recurrence in patients with bipolar disorder receiving treatment found that 58% of patients subsequently achieved recovery [25].

In this study, factors associated with a shorter time to syndromal recovery for 50% of the subjects were female sex, shorter index hospitalization, and lower initial depression ratings. The 43% who achieved functional recovery were more often older and had shorter index hospitalizations. Within 2 years of syn- 32 T. Treuer and M. Tohen dromal recovery, 40% experienced a new episode of mania (20%) or depression (20%), and 19% switched phases without recovery. Predictors of manic recurrence were initial mood-incongruent psychotic features, lower premorbid occupational status, and initial manic presentation.

Although there is agreement among researchers that bipolar spectrum disorders are severe, chronic, and lifelong conditions, and that breakthrough depression usually presents higher risks for long-term treatment than mania, there are several methodological issues in the study of the natural course of bipolar disorder [2]. Despite a considerable amount of research, the course and outcome of bipolar disorder still remain highly unpredictable. Likewise, it is difficult to determine the effect of treatment on the natural course of bipolar disorder that, despite treatment, still involves multiple relapses and impaired psychosocial functioning [3].

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