Breast Cancer (2nd Edition) by Daniel F. Roses
By Daniel F. Roses
This up to date re-creation presents an entire but concise knowing of breast cancer-from biology, pathology, and screening via prognosis, remedy, long term follow-up, and adjuvant care. Its functional, multidisciplinary concentration addresses the troubles of each member of the well-being care staff. a special question-and-answer structure bargains transparent solutions to medical questions, bettering communique between physicians, nurses, and patients.Considers the total variety of administration ideas, together with radiation remedy, chemotherapy, hormone remedy, and monoclonal antibody therapy.Uses a question-and-answer structure to make reference easy.Saves time by means of reading purely well-established, confirmed diagnostic and healing strategies.Incorporates new chapters on needle biopsy, lymph node pathology, sonography, new diagnostic imaging modalities, MRI, rising surgical techniques (such as radiofrequency and cryoablative techniques), and medicolegal issues.Offers brand-new insurance of lymphatic mapping and sentinel node biopsy, molecular pathology, and the most recent chemotherapeutic options.Presents 50% new individuals who're foreign leaders in molecular biology, genetics, radiology, pathology, surgical procedure, and oncology.Delivers approximately three hundred new scientific images and line illustrations.With 60 extra contributing specialists.
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Additional resources for Breast Cancer (2nd Edition)
An alternative view is that breast cancer is a disease of abnormal or uncontrolled proliferation resulting from deregulated growth factor signaling or aberrations in cell cycle control machinery. Thus, a great deal of interest has focused on the potential role of cell cycle elements in breast cancer. The cell cycle (Fig. 3–4) comprises four phases: G1(gap 1), S (DNA Mitogenic stimulus Mitogenic stimulus cycD cdk4 inactive cycE cycD p27 p27 cdk2 inactive cdk4 p27 active P P pRb cycE cdk2 inactive E2F P P P P pRb E2F active S-phase gene activation active Figure 3–4 Schematic diagram of activation of the cell cycle.
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Linkage of early-onset familial breast cancer to chromosome 17q21. Science 1990;250:1684–1689. 69. Wooster R, Neuhausen SL, Mangion J, et al. Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12–13. Science 1994;265:1088–1090. 25 70. Langston AA, Malone KE, Thompson JD, et al. BRCA1 mutations in a population-based sample of young women with breast cancer. N Engl J Med 1996;334:137–142. 71. Struewing JP, Abeliovich D, Peretz T, et al. The carrier frequency of the BRCA1 185delAG mutation is approximately 1% in Ashkenazi Jewish individuals.