Cancer and Zebrafish: Mechanisms, Techniques, and Models by David M. Langenau

By David M. Langenau

This quantity makes a speciality of defining the original attributes of utilizing the zebrafish melanoma version for locating vital pathways and capability drug ambitions for the remedy of human cancers. utilizing the zebrafish version, the quantity explores oncogene and tumor suppressor discovery, chemical genetic techniques, genomics, epigenetics, melanoma imaging, and telephone transplantation. Contributed chapters come from the main favorite laboratories operating during this box, which gives a different point of view on zebrafish versions from a large spectrum of the study group. additionally, the booklet deals a close research of the most up-tp-date learn within the sector for particular zebrafish melanoma types, together with T telephone leukemia, rhabdomyosarcoma, liver and pancreatic melanoma, cancer, neuroblastoma, germ phone tumors, and malignant peripheral sheath tumors. A bankruptcy is additionally devoted to the improvement and usage of alternative piscine types of melanoma. The compilation of chapters within the quantity culminates right into a entire and definitive textual content on zebrafish and melanoma, delivering a far wanted source at the robust attributes of the zebrafish version system.

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The leukemia model instead is highly lethal in double transgenic larvae and requires tol2 mediated The Toolbox for Conditional Zebrafish Cancer Models 27 mosaic integration of the oncogene construct in somatic cells to allow development of leukemia in juveniles [43]. In larvae the disease is characterized by prominent expansion of the caudal hematopoietic tissue and disruption of the vascular system and in adults appears through an increased number of immature cells and arrest of myeloid maturation in kidney marrow.

Padmanabhan A, Lee JS, Ismat FA, Lu MM, Lawson ND, Kanki JP, Look AT, Epstein JA (2009) Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI. Proc Natl Acad Sci U S A 106:22305–22310 62. Park JT, Leach SD (2013) TAILOR: transgene activation and inactivation using lox and rox in zebrafish. PLoS One 8, e85218 63. Taylor AM, Zon LI (2009) Zebrafish tumor assays: the state of transplantation. Zebrafish 6:339–346 64. Tang Q, Abdelfattah NS, Blackburn JS, Moore JC, Martinez SA, Moore FE, Lobbardi R, Tenente IM, Ignatius MS, Berman JN et al (2014) Optimized cell transplantation using adult rag2 mutant zebrafish.

Juvenile tumor carriers, generated through somatic oncogene expression, reveal massive telencephalic tumors resembling human malignant glioma. In another glioma study, Ju et al describe the induction of malignant brain tumors in zebrafish by expression of mCherry fused KRASG12V under two different neural promoters, krt5 and gfap [44]. While both models develop brain tumors in about 50 % of fish at 1 year of age, tumor type and histology are different with the krt5 promoter inducing mostly MPNST (malignant peripheral nerve sheath tumor)—tumors and gfap promoter mainly tumors of the brain parenchyma.

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