Cancer Genes: Functional Aspects by Gerard I. Evan, Elizabeth H. Harrington, Nicola J. McCarthy

By Gerard I. Evan, Elizabeth H. Harrington, Nicola J. McCarthy (auth.), Enrico Mihich, David Housman (eds.)

The built-in keep watch over of cellphone Proliferation and telephone Viability; G.I.Evan, et al. keep an eye on of Invasive telephone progress by way of the MET family members Oncogenes; F. Galimi, P.M. Comoglio. Src kin Kinases and the cellphone Cycle; S.A. Courtneidge. p16 kinfolk Inhibitors of Cyclin-Dependent Kinases; Y. Li, et al. p53-Mediated Apoptosis: Regulatory and Mechanistic features; Y. Haupt, et al. The Molecular Genetics of Wilms Tumor; J. Pelletier, et al. HTLV-1 Tax: A Paradigm for the way a unmarried Auxiliary issue Can keep watch over the Expression of Viral and mobile Genes; G. Perini, M.R. Green. CREM: Transcriptional Pacemaker of the cAMP reaction; J.S. Lee, et al. MADS-domain transcription issue and Their accent Proteins (TCFs): Nuclear goals for progress regulate indications; M.A. Cahill, et al. Retinoblastoma Protein, Gene Expression, and cellphone Cycle keep an eye on; J.C. Azizkhan, et al. Cyclin A-kinase Binding to and legislation of the functionality of a Growth-Promoting Transcription issue; W. Krek, et al. Homeostatic Mechanisms Governing the cross hase as outlined by means of the Gas Genes; C. Schneider, et al. The TEL Gene and Human Leukemias; T.R. Golub, et al. Characterization of the TCLI Gene and Its Involvement in T-Cell Malignancies; L. Virgilio, et al. three extra Articles. Index.

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The maturation of pro-HGF to functional HGF is a crucial point in the physiology of the factor. ,1993). , 1995). In a standard catalytic reaction, given enough time, virtually all the substrate is processed and the total yield of product is independent from the concentration of enzyme. The reaction is only limited by the initial substrate concentration. On the contrary, for uPA and HGF the limiting factor is the amount of enzyme and not the amount of substrate. The stoichiometric reaction of uPA with pro-HGF could be due either to the formation of a stable complex between the reaction products or to ,im irreversible modification of uP A in the course of its reaction with pro-HGF.

We have done and published an experiment where we chopped HGF which is an enormous molecule and made it smaller, smaller and smaller. So, as I told you, if we remove the beta chain, the protease-like chain, cells scatter but do not grow. And the same if we remove the two kringles and the same is that if we save the hairpin loop and the first kringle. So we have a minimal segment which contains the first loop, the first kringle domain of the N-terminal portion of the alpha chain which induces scattering but not mitogenesis.

Chern. 266, 16098-16104. , Follenzi. J. M. (1994). Ron is a heterodimeric tyrosine kinase receptor activated by the HGF-homolog MSP. , 13, 3524--3532. , and Furlong, R. (1989). Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interaction and movement. Proc. Natl. Acad. Sci. USA 86, 5844--5848. , Rosa, C. M. (I 989b) Biosynthesis of the protein encoded by the c-METproto-oncogene. Oncogene 4, 1383-1388. S. M. (1989a) Tyrosine kinase receptor indistinguishable from the c-Met protein.

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