By Jean Louis Guénet, Fernando Benavides, Jean-Jacques Panthier, Xavier Montagutelli
This booklet, written by means of skilled geneticists, covers themes starting from the typical historical past of the mouse species, its dealing with and copy within the laboratory, and its classical genetics and cytogenetics, to fashionable concerns together with the research of the transcriptome, the parental imprinting and X-chromosome inactivation. The recommendations for developing every type of mutations, both by means of genetic engineering or through the use of mutagens, also are reviewed and mentioned intimately. eventually, a final bankruptcy outlines the technique used for the research of complicated or quantitative traits.
The authors additionally speak about the significance of actual phenotyping, that is now played within the mouse clinics verified around the globe and determine the boundaries of the mouse version, which lower than yes situations can fail to offer the phenotype anticipated from the cognate situation within the human version. for every bankruptcy an updated checklist of pertinent references is supplied.
In brief, this ebook bargains an important source for all scientists who use or plan to exploit mice of their research.