Cell entry by non-enveloped viruses by Amy Odegard, Manidipa Banerjee, John E. Johnson (auth.),
By Amy Odegard, Manidipa Banerjee, John E. Johnson (auth.), John E. Johnson (eds.)
Non enveloped viruses represent an enormous classification of medically major pathogens. They encode their proteins in unmarried (ss) and double strand (ds) RNA and DNA genomes and show a number of sizes and buildings. during this quantity specialists within the box supply brand new descriptions of many features linked to the ssRNA noda, picorna and calciviruses, the dsRNA reo and rotaviruses, the ssDNA parvoviruses and the dsDNA polyoma and adenoviruses. whereas many facets of those viruses were addressed formerly, this quantity in particular specializes in the problem in their access into cells, with specific recognition to the translocation of the viral genome via a membrane, with no assistance from inter-membrane fusion that's universal and fairly good understood in enveloped viruses. enough aspect has been published in many of the viruses mentioned during this quantity to set up a reputable argument for convergent evolution. numerous mechanisms are defined to generate and tightly keep an eye on the publicity of a fusion-like peptide or a complete gene product that enables membrane permeation and genome supply into the cytoplasm and, for the DNA viruses, the nucleus. on account that there's no viral membrane to fuse with the mobile membrane, the occasions at this interface are assorted from these linked to enveloped viruses and with a number of the fusion occasions linked to general mobile functionality. therefore, whereas the standards serious for this strategy to happen were good validated for lots of of those viruses, a selected mechanism for genome penetration is but to be decided. We think that this quantity will offer a reference of tolerating worth for the non enveloped virus box and our wish is that the point of interest on access and genome translocation throughout a mobile membrane will stimulate new principles and mechanistic reports of this significantly vital process.
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Extra info for Cell entry by non-enveloped viruses
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3)]-D-Gal). These glycans bind to essentially the same location: at the interface between the two subunits and at the outer most tip of the P2 domain. The ability to recognize both types of glycans is likely due to the fact that most of the protein/ligand interactions are via the fucose moiety that is common to both. While the binding pocket lies at the P2 dimeric interface, the predominant interactions lie on one side of the dimer. Subsequently, similar studies were performed on Norwalk P domains (Bu et al.