Chromosomal Instability in Cancer Cells by B. Michael Ghadimi, Thomas Ried

By B. Michael Ghadimi, Thomas Ried

This factor of Recent leads to melanoma Research provides a finished evaluation of present knowing of chromosomal instability in melanoma and of recommendations to take advantage of this data for greater remedy of sufferers with melanoma. melanoma is a ailment of the chromosomes, and chromosomal instability in melanoma disrupts gene functionality through both inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal foundation for those aberrations is both translocations, which switch the integrity of genes, or irregular numbers of chromosomes, a known as aneuploidy, which ends up in irregular gene expression degrees. Such structural or numerical chromosomal aberrations are particular for designated tumor entities. The measure of chromosomal instability and the measure of intratumor heterogeneity have profound results for ailment consequence and for healing stratification.

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Nature 402:187–191 Yang H, Jeffrey PD, Miller J et al (2002) BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. Science 297:1837–1848 Yates LR, Campbell PJ (2012) Evolution of the cancer genome. Nat Rev Genet 13:795–806 Yu CE, Oshima J, Fu YH et al (1996) Positional cloning of the Werner’s syndrome gene. Science 272:258–262 Zhang Y, Gostissa M, Hildebrand DG et al (2010) The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers.

2001). 3 Chromothripsis The occurrence of very complex chromosomal rearrangements involving one or just a few chromosomes is called chromothripsis (chromosome shattering). These events have just recently become amenable to analysis through whole cancer genome sequencing approaches (Stephens et al. 2011). It is likely that chromosthrispsis events originate from replication fork stalling and template switching (Lee et al. 2007) or alternatively from microhomology-mediated break-induced replication (Hastings et al.

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