Colorectal Cancer Screening by Petr Protiva (auth.), Joseph Anderson, MD, Charles Kahi, MD

By Petr Protiva (auth.), Joseph Anderson, MD, Charles Kahi, MD (eds.)

Colorectal melanoma Screening offers a whole assessment of colorectal melanoma screening, from epidemiology and molecular abnormalities, to the newest screening options comparable to stool DNA and healthy, automated Tomography (CT) Colonography, excessive Definition Colonoscopes and slim Band Imaging. because the textual content is dedicated solely to CRC screening, it gains many proof, rules, directions and figures relating to screening in a simple entry layout. This quantity presents a whole advisor to colorectal melanoma screening to be able to be informative to the subspecialist in addition to the first care practitioner. It represents the single textual content that offers this brand new information regarding an issue that's constantly altering. For the first practitioner, details at the directions for screening in addition to expanding sufferer participation is presentedd. For the subspecialist, information about the most recent imaging strategies in addition to flat adenomas and chromoendoscopy are coated. The part at the molecular adjustments in CRC will attract either teams. The textual content contains brand new information regarding colorectal screening that encompasses the total spectrum of the subject and lines pictures of polyps in addition to diagrams of the morphology of polyps in addition to pictures of CT colonography photographs. Algorithms are offered for the entire instructed guidelines.

Chapters are dedicated to sufferer participation in screening and danger elements in addition to new imaging expertise. this beneficial quantity explains the reason in the back of screening for CRC. furthermore, it covers the various screening concepts in addition to the functionality features, while to be had within the literature, for every try out. This quantity might be utilized by the sub experts who practice screening checks in addition to fundamental care practitioners who refer sufferers to be screened for colorectal cancer.

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Extra resources for Colorectal Cancer Screening

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Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer. J Natl Cancer Inst. 2002;94:972–80. 90. Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM. Prevalence of overweight and obesity in the United States, 1999–2004. JAMA. 2006;295:1549–55. 91. Yamaji Y, Okamoto M, Yoshida H, Kawabe T, Wada R, Mitsushima T, et al. The effect of body weight reduction on the incidence of colorectal adenoma. Am J Gastroenterol. 2008;103:2061–7.

Lieberman DA, Prindiville S, Weiss DG, Willett W. Risk factors for advanced colonic ­neoplasia and hyperplastic polyps in asymptomatic individuals. JAMA. 2003;290:2959–67. 115. Anderson JC, Latreille M, Messina C, Alpern Z, Grimson R, Martin C, et al. Smokers as a high-risk group: data from a screening population. J Clin Gastroenterol. 2009;43:747–52. 116. Botteri E, Iodice S, Raimondi S, Maisonneuve P, Lowenfels AB. Cigarette smoking and adenomatous polyps: a meta-analysis. Gastroenterology. 2008;134:388–95.

Most experts recommend these families be considered distinct from families with MSI or MMR gene mutations and referred to as “familial colorectal cancer type X” [23]. The families with evidence of MSI or an MMR gene mutation should be referred to as LS. Large studies have shown that non-LS families are only at an increased cumulative lifetime risk of CRC, not extracolonic cancers, usually with a later age of onset and lower penetrance of disease than LS patients [23, 24]. It is also reported that CRC in non-LS patients is primarily leftsided and lacks the MSI-H pathology of tumors seen in LS [25–27].

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