Current Concepts in Kidney Transplantation by Mithat Tabaković, Nermin N. Salkić, Fahir Baraković, Senaid
By Mithat Tabaković, Nermin N. Salkić, Fahir Baraković, Senaid Trnačević
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In 15% of the cases, the transmission is autosomal recessive, and is caused by mutations affecting COL4A3 or COL4A4 located on chromosome 2. The autosomal dominant form of Alport syndrome is very rare and is caused by heterozygous mutations in COL4A3 or COL4A4 genes. Affected individuals can also have sensironeural hearing loss and ocular abnormalities. Sensorineural hearing loss is the most common extrarenal manifestation and the progression of hearing loss often parallels the progression of renal disease.
Transplantation 2009;87:1381-1386.  Eckel RH. Nonsurgical Management of Obesity in Adults. New England Journal of Medicine 2008;358: 1941-1950.  Abbott KC, Glanton CW, Agodoa LY. Body Mass Index and Enrollment the Renal Transplant Waiting List in the United States. Journal of Nephrology 2003;16: 40-48.  Weissenbacher A, Maximilian J, Ulmer H, et al. Recipient and Donor Body Mass Index as Important Risk Factors for Delayed Graft Function. Transplantation 2012;93: 524-529.  Alexander JW, Goodman HR, Gersin K, et al.
Rituximab Targets Podocytes in Recurrent Focal Segmental Glomerulosclerosis. Science Translational Medicine 2011;3(85): 85ra46.  Vivarelli M, Pasini A, Emma F. Eculizumab for the Treatment of Dense-Deposit Disease. New England Journal of Medicine 2012;366(12): 1163-1165.  Daina E, Noris M, Remuzzi G. Eculizumab in a Patient with Dense-Deposit Disease. New England Journal of Medicine 2012;366(12): 1161-1163.  Radhakrishnan S, Lunn A, Kirschfink M, et al. Eculizumab and Refractory Membranoproliferative Glomerulonephritis.