Drug Delivery in Cancer Treatment by L. Domellöf (auth.), Lennart Domellöf (eds.)

By L. Domellöf (auth.), Lennart Domellöf (eds.)

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It is important to be aware of this problem since the appetite-influencing activity of many immune substances, such as interleukins and interferons, though well recognized experimentally, is usually not emphasized in the clinical setting. This effect of recombinant drug prescriptions may be of great quantitative importance, since an increasing number of outpatients will be subjected to immune treatment over long periods when indications for such drugs are more diversified. A reduced food intake in the range of 5-10% will lead to a severely altered body composition within 6 months.

Preliminary investigations in our laboratory have demonstrated that the major effect of nutritional support is to slow down the weight loss, while stimulation to resynthesis of the majority of proteins, particularly in peripheral tissues, demands powerful treatment. In such cases, nutrition-associated side effects such as vomiting, fluid retention and respiratory distress are not unusual. Our own research has demonstrated that cancer patients can utilize non-protein calories (fats and carbohydrates) in a normal and efficient way to produce energy and rebuild energy depots [24].

Pts,. s. ) [9] [10] [11 ] [12] [13] [14] [15] [16]*·* * studies in children; *. =not stated bottom of the reservoir is felt. The feel of the needle passing through the septum is sufficient to prevent subcutaneous injection. The use of a Huber point needle, which has its opening at the side, should prevent coring out pieces from the septum. It is also important to emphasize here that the reservoir of an implantable treatment device should not be located too deeply beneath the skin surface, since this will hamper the undisturbed use of the system.

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