Electrophysiology of the Neuron: An Interactive Tutorial by John Huguenard

By John Huguenard

This guide and disk, to be had in IBM workstation and Macintosh codecs, accompanies Shepherd's Neurobiology, 3/e. it may be used individually although it is keyed to the textbook. The 17 experiments examine such parts because the resting membrane strength, motion strength, voltage clamp, physiological houses of nerve cells, and synaptic potentials. this system permits scholars to propagate the motion capability, modify a number of parameters and detect the results on nerve cellphone firing. scholars will know about equilibrium potentials and the consequences of adjusting ion concentrations, in addition to passive and lively membrane homes. Separate experiments research sodium ion and potassium ion currents, the voltage dependence of those currents, and sleep vs. waking in unmarried neurons. research questions are supplied all through. This ingeniously-designed software will profit all undergraduate scholars of neuroscience.

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During slowwave sleep, this cell generates bursts of action potentials (labeled bursts and expanded for detail). In the transition to REM sleep (or waking) the membrane potential depolarizes by 10 to 20 mV and the cell generates a series of single action potentials (labeled single spikes and expanded for detail). The transition back to slow-wave sleep is again associated with hyperpolarization of the membrane. ) 44 ELECTROPHYSIOLOGY OF THE NEURON results in only the passive response of the cell, which is shaped by the resistive and capacitive properties of the cell.

Activation of the EPSP alone results in an action potential. Activation of the Cl--mediated IPSP alone at a membrane potential of -85 mV results in a depolarizing IPSP (dashed line). Activation of the EPSP and IPSP together results in inhibition of the EPSP so that it no longer activates an action potential. 60 ELECTROPHYSIOLOGY OF THE NEURON Study Questions: Synaptic Potentials 1. What is the effect of release of glutamate onto a cell? How about GABA? ) 2. If the extracellular concentration of Cl was equal to the intracellular concentration, would activation of GABAA receptors be inhibitory or excitatory?

Study Questions: Multiple Ionic Currents in Central Neurons 1. What is a major difference between the A-current and the "delayed rectifier" K+ current that repolarizes action potentials? ) 2. How are Ca++-activated K+ currents important for action-potential generation? ) 3. Which current allows cells to generate bursts of action potentials at one membrane potential and trains of action potentials at another (Figure 24)? Why? 4. How is the M-current different from the "delayed rectifier" K+ current underlying action-potential repolarization (compare Figures 27 and 10).

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