Esophageal Cancer - Cell and Molec. Biology, Biomarkers, by F. Jazii

By F. Jazii

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The contribution of Ras/ERK signaling has been demonstrated by Senmaru et al. They have shown a dominant negative H-ras mutant (N116Y) inhibits EGF-stimulated activation of Erk2 in esophageal cancer cells. Furthermore, using adenoviral vectors and increased expression of this mutant significantly reduces the growth of human squamous cell carcinoma of esophagus cells in vitro and in vivo [98]. Furthermore, the significance of Ras signaling and its downstream pathways has also been recently indicated in tumorigenesis of esophageal cancer.

FEBS Lett 1997;410: 83–6. , HER-2/neu: A differentiation marker in adenocarcinoma of the esophagus. Cancer Lett 1993; 75: 41– 44. , c-erbB-2 overexpression in the dysplasia/carcinoma sequence of Barrett’s oesophagus. J Clin Pathol 1995; 48: 129 –132. , Coamplification and coexpression of GRB7 and ERBB2 is found in high grade intraepithelial neoplasia and in invasive Barrett’s carcinoma. Int J Cancer 2004; 112: 747–753. , Prognostic value of Lauren classification and c-erbB-2 oncogene overexpression in adenocarcinoma of the esophagus and gastroesophageal junction.

Fontolliet, C. (2002). Beta-catenin expression and its association with prognostic factors in adenocarcinoma developed in Barrett esophagus. Am J Clin Pathol 117(3): 451-456. , & Moustakas, A. (2007). Actions of TGF-beta as tumor suppressor and prometastatic factor in human cancer. Biochim Biophys Acta 1775(1): 21-62. , & Reid, B. (2009). Chromosomal instability and copy number alterations in Barrett's esophagus and esophageal adenocarcinoma. Clin Cancer Res 15(10): 3305-3314. , & Jenuwein, T.

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