Functionalized Conjugated Polyelectrolytes: Design and by Shu Wang, Fengting Lv (auth.)

By Shu Wang, Fengting Lv (auth.)

Functionalized Conjugated Polyelectrolytes presents a entire evaluation of those polyelectrolytes and their biomedical purposes. easy points like molecular layout and optoelectronic houses are coated within the first bankruptcy. Emphasis is put on some of the purposes together with sensing (chemical and biological), sickness analysis, mobilephone imaging, drug/gene supply and sickness remedy. This ebook explores a multi-disciplinary subject of curiosity to researchers operating within the fields of chemistry, fabrics, biology and drugs. It additionally deals an built-in standpoint on either easy learn and alertness concerns. Functionalized conjugated polyelectrolyte fabrics, that have already drawn massive curiosity, turns into an incredible new course for biomedicine development.

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The yellow solution of cationic PT corresponds to short-wavelength absorption owing to the limited conjugation length. However, the addition of negatively charged capture oligonucleotide probes could transform the backbone of PT into a more planar conformation by forming duplex strands, and the solution color changed into red. In this case, the fluorescence of PT 23 was dramatically quenched due to the formation of planar duplex aggregates. However, in the presence of complementary oligonucleotides, the formative triplex composed of hybridized double strands and cationic PTs led to a 15-fold enhanced fluorescence.

However, the addition of negatively charged capture oligonucleotide probes could transform the backbone of PT into a more planar conformation by forming duplex strands, and the solution color changed into red. In this case, the fluorescence of PT 23 was dramatically quenched due to the formation of planar duplex aggregates. However, in the presence of complementary oligonucleotides, the formative triplex composed of hybridized double strands and cationic PTs led to a 15-fold enhanced fluorescence.

Kwon IK, Kim JP, Sim SJ (2010) Enhancement of sensitivity using hybrid stimulus for the diagnosis of prostate cancer based on polydiacetylene (PDA) supramolecules. Zheng W, He L (2010) Multiplexed detection of protein cancer markers on au/ag-barcoded nanorods using fluorescent-conjugated polymers. Yao Z, Feng X, Li C, Shi G (2009) Conjugated polyelectrolyte as a colorimetric and fluorescent probe for the detection of glutathione. Fan H, Zhang T, Lv S, Jin Q (2010) Fluorescence turn-on assay for glutathione reductase activity based on a conjugated polyelectrolyte with multiple carboxylate groups.

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