Genes and Common Diseases: Genetics in Modern Medicine by Alan Wright, Nicholas Hastie

By Alan Wright, Nicholas Hastie

Genes and customary ailments offers an updated view of the position of genetics in sleek drugs, reflecting the strengths and obstacles of a genetic point of view. the present shift in emphasis from the learn of infrequent unmarried gene issues to universal ailments brings genetics into each element of contemporary medication, from infectious ailments to therapeutics. even though, it truly is doubtful no matter if this more and more genetic spotlight will end up important within the face of significant environmental impacts in lots of universal ailments. The e-book takes a troublesome and self-critical examine what can and can't be completed utilizing a genetic procedure and what's identified approximately genetic and environmental mechanisms in numerous universal illnesses. It seeks to elucidate the targets of human genetic examine via supplying state-of-the artwork insights into identified molecular mechanisms underlying universal illness strategies whereas even as offering a pragmatic review of the anticipated genetic and physiological complexity.

Show description

Read or Download Genes and Common Diseases: Genetics in Modern Medicine PDF

Best genetics books

The Genetic Gods: Evolution and Belief in Human Affairs

John Avise offers a overview of latest molecular biology that is fairly obtainable to the 'lay' reader with a few past publicity to the overall sector of evolutionary-genetics. The discussions are a bit of philosophically charged (i. e. they don't stay inevitably technical) and comment on social, emotional, and theological matters too.

Natural Genetic Engineering and Natural Genome Editing (Annals of the New York Academy of Sciences)

The new literature on entire genome sequences offers considerable proof for the motion of normal genetic engineering in evolution. Discoveries approximately average genetic engineering have coincided with quick growth in our figuring out of epigenetic keep watch over and RNA-directed chromatin formation. exact consciousness should be paid to the position of viruses and similar so-called "parasitic" components within the starting place of genome formatting and usual genetic engineering features in particular the position of non-random genetic swap operators within the construction of advanced evolutionary innovations.

Evolution and Genetics of Populations. Volume 4: Variability within and among natural populations

"Wright's perspectives approximately inhabitants genetics and evolution are so basic and so entire that each critical scholar needs to research those books firsthand. . . . e-book of this treatise is an enormous occasion in evolutionary biology. "-Daniel L. Hartl, BioScience

Extra resources for Genes and Common Diseases: Genetics in Modern Medicine

Sample text

And Kadonaga, J. T. (2003). The RNA polymerase II core promoter. Annu Rev Biochem, 72, 449–79. Smith, C. W. and Valcarcel, J. (2000). Alternative premRNA splicing: the logic of combinatorial control. Trends Biochem Sci, 25, 381–8. Spector, D. L. (2003). The dynamics of chromosome organization and gene regulation. Annu Rev Biochem, 72, 573–608. Spotswood, H. T. and Turner, B. M. (2002). An increasingly complex code. J Clin Invest, 110, 577–82. , Stevenin, J. and Soret, J. (2001). SC35 autoregulates its expression by promoting splicing events that destabilize its mRNAs.

Hentze, M. W. and Kulozik, A. E. (2004). Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife. Genome Biol, 5, 218. , Renkawitz, R. and Lobanenkov, V. (2001). CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease. Trends Genet, 17, 520–7. , Lagrange, T. and Reinberg, D. (1996). The general transcription factors of RNA polymerase II. Genes Dev, 10, 2657–83. Orphanides, G. and Reinberg, D. (2002). A unified theory of gene expression. Cell, 108, 439–51.

Some of the modifications shown are mutually exclusive. Blue boxes indicate lysine (K) acetylation, green boxes indicate serine (S) phosphorylation and red boxes indicate lysine methylation. Ub indicates ubiquitination. , 2004). How histone variants substitute for their canonical counterparts remains an intriguing question. Normally nucleosomes are reassembled after cell division, concurrent with the replication process. 3. A further possibility is the existence of protein complexes that can facilitate the exchange between histones and their variant counterparts in interphase chromatin.

Download PDF sample

Rated 4.46 of 5 – based on 21 votes