Genetics Meets Metabolomics: from Experiment to Systems by Karsten Suhre (auth.), Karsten Suhre (eds.)

By Karsten Suhre (auth.), Karsten Suhre (eds.)

This publication is written via prime researchers within the fields in regards to the intersection of genetics and metabolomics which can result in extra entire experiences of inborn version of metabolism.

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Extra info for Genetics Meets Metabolomics: from Experiment to Systems Biology

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G. LC-MS/MS, these amino acids can be differentiated [73] as follows: Presetting a specific collision energy, butylated acidic groups of Leu and Ile allow an initial loss of butyl formate creating m/z 86+ product ions. A subsequent fragmentation creates even smaller ions (69+, 43+ and 68+ for Ile, Leu and OH-Pro, respectively), which can finally be used to distinguish these amino acids. Although Leu and Ile both fragment to the characteristic carbonium ion structures at 43+ and 69+, Leu shows only a minor 69+ product ion and Ile has no 43+ but a relatively strong 57+ instead (Fig.

Like in other chromatographic techniques, a mobile and a stationary phase are required. g. helium, argon, or nitrogen. g. dimethyl polysiloxane). The carrier gas flows continuously through the injection port, column and detector. The sample is injected into the heated injection port, where it is vaporized and carried into the capillary column. In the capillary column, the sample analytes are separated according to their respective retention times on the stationary phase. Thereby, the retention time is dependent on the relative solubility of compounds in the liquid phase (and dependent on the relative vapor pressure).

Chace DH, Hillman SL, Van Hove JL, Naylor EW (1997) Rapid diagnosis of MCAD deficiency: quantitative analysis of octanoylcarnitine and other acylcarnitines in newborn blood spots by tandem mass spectrometry. Clin Chem 43(11):2106–2113 35. Zivkovic AM, Wiest MM, Nguyen UT, Davis R, Watkins SM, German JB (2009) Effects of sample handling and storage on quantitative lipid analysis in human serum. Metabolomics 5(4):507–516 36. Morrow JD, Roberts LJ 2nd (1994) Mass spectrometry of prostanoids: F2-isoprostanes produced by non-cyclooxygenase free radical-catalyzed mechanism.

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