Genetics of Steroid Biosynthesis And Function by J.I. Mason

By J.I. Mason

This quantity offers an obtainable, updated review of contemporary steroid biology for either the pro and amateur researcher alike.

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Biochemistry 38, 1598–1606. J. L. (1997) Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia. Proc. Natl. Acad. Sci. A. 94, 11540–11545. P. and Kammerman, S. (1974) Binding of gonadotropins to ovarian cells. Biol Reprod. 10, 179–198. , Defaye, G. M. (1994) Characterization of the 3β-hydroxy steroid dehydrogenase activity associated with bovine adrenal cortical mitochondria. Endocrinology 134, 1358–1364.

J. Steroid Biochem. Molec. Biol. 40, 537–543. T. B.

Few other examples exist that have been studied so completely. LESSONS FROM PREGNANCY AND PARTURITION A clear, anatomical separation of androgen and estrogen synthesis is also seen in a number of cases during pregnancy (Geisert and Conley, 1998). , 1998). However, neither CYP17 expression nor activity is detectable in human placenta, and androgens aromatized in situ have their origins in the fetal zone of the developing fetal adrenal gland (Simpson and MacDonald, 1981), as noted previously. Therefore, rather than a co-ordinated “two-cell” system, two separate fetal organs participate in estrogen synthesis during pregnancy.

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