Guide to Targeted Therapies: Treatment Resistance in Lung by Federico Cappuzzo

By Federico Cappuzzo

This textual content is a concise and updated evaluation, which discusses the heritage, improvement and mechanisms of resistance, checking out equipment and expertise, present and rising treatments and assets that clinicians promises to their sufferers. Busy healthcare pros who desire a speedy assessment of therapy resistance in lung melanoma in addition to a precis of present treatments will reap the benefits of this succinct guide.

Show description

Read or Download Guide to Targeted Therapies: Treatment Resistance in Lung Cancer PDF

Best cancer books

Cancer: Basic Science and Clinical Aspects

This ahead taking a look melanoma biology ebook appeals to a panoramic viewers. Introductory chapters that offer the molecular, mobile, and genetic details had to understand the cloth of the following chapters deliver unprepared scholars in control for the remainder of the publication and function an invaluable refresher for people with earlier biology historical past.

THE COMPLETE IDIOT'S GUIDE TO LIVING WITH BREAST CANCER

This advisor is for breast melanoma sufferers, their spouses and kids, and their households, co-workers, and pals. the writer hopes to reply to the sensible, way of life questions that each breast melanoma sufferer or family member has. The booklet offers info, suggestions, information, and proposal for every little thing from that first biopsy to the five-year check-up.

Gastrointestinal Cancer (M.D. Anderson Cancer Care Series)

Gastrointestinal melanoma comprises melanoma of the digestive method - the esophagus, colon, rectum, anus, liver, pancreas, and different digestive organs. Taken as a complete, there are an envisioned 250,600 new instances within the US. Colon and rectum melanoma is the 3rd best reason for melanoma and melanoma deaths within the US.

Camptothecins in Cancer Therapy (Cancer Drug Discovery and Development)

A serious assessment our present knowing of camptothecins, their shortcomings, and of the probabilities for making improvements to their medical functionality. The authors talk about new camptothecin analog improvement, drug supply matters for optimizing their anticancer task, and their strength use in numerous diverse cancers.

Additional info for Guide to Targeted Therapies: Treatment Resistance in Lung Cancer

Example text

2012;13:1011-1019. 68 Shaw AT, Kim DW, Nakagawa K, et al. Crizotinib versus chemotherapy in advanced ALKpositive lung cancer. N Engl J Med, 2013; 368: 2385–94. 69 Mok T, Kim D-W, Wu Y-L, et al. First-line crizotinib versus pemetrexed–cisplatin or pemetrexed– carboplatin in patients (pts) with advanced ALK-positive non-squamous non-small cell lung cancer (NSCLC): results of a phase III study (PROFILE 1014). J Clin Oncol. 2014; 32:5s (suppl; abstr 8002). 70 Kwak EL, Camidge DR, Clark J, et al. Clinical activity observed in a phase I dose escalation trial of an oral anti c-met and ALK inhibitor, PF-02341066.

Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer. J Clin Oncol. 2010; 28: 357-360. 2 Chaft JE, Oxnard GR, Sima CS, et al. Disease flare after tyrosine kinase inhibitor discontinuation in patients with EGFR-mutant lung cancer and acquired resistance to erlotinib or gefitinib: implications for clinical trial design. Clin Cancer Res. 2011;17:6298-6303. 48 • GUID E TO TA R G E TE D THE R A P IE S: T RE AT M E N T RE S IS TA N CE IN LU N G C AN C E R 3 Guo R, Chen X, Wang T, et al.

A randomized phase II study of erlotinib alone or in combination with linsitinib (OSI-906), an orally bioavailable small molecule inhibitor of IGF1R, in patients with advanced EGFR mut+ NSCLC was prematurely closed for futility (NCT01221077). The potential efficacy of rociletinib in the T790M-negative population could be, at least in part, related to IGF1R inhibition. Hyperglycemia, a frequent adverse event associated with rociletinib exposure, is related to a rociletinib metabolite that is able to inhibit IGF1R.

Download PDF sample

Rated 4.73 of 5 – based on 20 votes