Imidazole Dipeptides: Chemistry, Analysis, Function and by Victor R Preedy (ed.)
By Victor R Preedy (ed.)
Carnosine and anserine are universal histidine-derived dipeptides, sometimes called imidazole dipeptides, present in muscle and mind tissues of animals. Their nutritional and dietary value lies of their antioxidant homes and a couple of investigators are different future health advantages of the compounds.
This quantity surveys the present kingdom of play in those and different components of curiosity, together with chemistry and biochemistry, immunology and mobile homeostasis. Chapters glance extensive at many of the capabilities and results within the physique really with reference to workout and fatigue, wound therapeutic, melanoma remedy and age-related ailments. offering an up to the moment, interdisciplinary procedure, this e-book is of serious curiosity to researchers and pros in chemistry, nutrients technological know-how, food, biochemistry, future health sciences and activities sciences.
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Additional info for Imidazole Dipeptides: Chemistry, Analysis, Function and Effects
When considering the described quenching mechanism, it is not surprising that the N-acetylation completely removes the quenching activity towards HNE and this finding can be seen as a further confirmation of the role played by the imino intermediate. , 2013). 2, 6) is an endogenous dipeptide distributed in cerebral regions and cerebrospinal fluid where it can act as a reservoir for the neurotransmitter GABA. 1 Comparison of some biochemical properties of carnosine and derivatives. d. d. d. d.
View Online 12:16:39. 1039/9781782622611-00023 Carnosine and Its Homologs in Foods 25 The carnosine present in the human body comes both from endogenous and from exogenous sources. The endogenous part is synthesized from the essential amino acids, alanines and histidines through the action of a specific synthetase, carnosinase, while diet provides all exogenous carnosine, and is capable of introducing approximately 50/250 mg per day (when at least one portion of beef, pork or chicken is consumed per day).
They analyzed the consumption of trans-2hexenal when incubated with a set of nucleophilic peptides. Albeit without determining the precise quenching mechanism, the study first revealed the remarkable quenching activity of carnosine and some analogs. The obtained results evidenced that the tested nonhistidine-containing dipeptides are understandably devoid of quenching activity, while the proteinogenic histidine-containing dipeptides show a clear quenching activity although, on average, it is less pronounced than that of carnosine.