Immunoterapy of Cancer by M. Disis

By M. Disis

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In our priming experiments, we have also used IL-12, because it has been reported that regulation of IFN-γ production in stimulated peripheral blood mononuclear cell (PBMC) cultures requires direct involvement of IL-12. Such cytokine modulation of the priming conditions gave rise to antigen-specific, granulocyte/macrophage colony-stimulating factor (GM-CSF)- and IFN-γ-secreting cells. Synergistic effects of IL-4 with IL-12 on IFN-γ production by DC have also been reported (54,55). IL-12 is known to promote a potent cellular immune response in which tumor-specific CTL and Th cells are induced to secrete Th1 cytokines (56–58).

Identification of tumor-restricted antigens NY-BR-1, SCP-1, and a new cancer/testis-like antigen NW-BR-3 by serological screening of a testicular library with breast cancer serum. Cancer Immun 2002; 2:5. 93. Heath JK, White SJ, Johnstone CN, et al. The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily. Proc Natl Acad Sci USA 1997; 94:469–474. 94. Tsang KY, Zaremba S, Nieroda CA, et al. Generation of human cytotoxic T cells specific for human carcinoembryonic antigen epitopes from patients immunized with recombinant vaccinia-CEA vaccine.

Most of the yet known MHC peptides were isolated by this method or modifications thereof. de). Because of the central importance of this technique, we describe our own approach in detail. The source material for this isolation approach is normally frozen tissue, blood cells, or pellets from cultured cell lines. Requirements for providing good amounts of peptides for sequence analysis are about 109 cells; however, with improvements made in mass spectrometry (MS), this amount is continuously decreasing.

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