Integrative Hypothalamic Activity by D.F. Swaab, J.P. Schade

By D.F. Swaab, J.P. Schade

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This disclosure disposed of the then widely held belief that NSM was a glycolipoprotein “bearer substance” which could not, by virtue of its cytochemical properties, represent the posterior pituitary principles. In a letter passed to one of us, Sloper related how, in retrospect, he had often smiled at himself with regard to this early work. , 1942) had already identified cystine in his protein some 10 years earlier. 2 mm/h, was in a downward direction, though, as he stated, some of the flow could also be centripetal (p.

Nauta set himself this task, first at the University of Utrecht here in Holland (until 1947) and then at the University of Zurich (until 1951). In Zurich, he finally devised a modification of the Bielschowsky method which was capable of impregnating degenerating nerve fibers, so that the axons undergoing degeneration looked something like a string of black beads against a yellow-brown background. He was urged by co-workers in Zurich to put his new References p. 52-60 46 E. ANDERSON AND W. HAYMAKER Fig.

This concept led him to look for experimental confirmation, which could be obtained only by subcortical stimulation. Acute experiments were usually carried out, chronic experiments only occasionally, for he found that his rigid steel electrodes too frequently caused local tissue destruction. “It was my goal”, Hess (1963) stated, “to test the behavior of experimental animals (cats) subjected to electrical stimulation and diathermic lesions without impairing the freedom of movement of the animal by immobilization or narcosis” (p.

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