Interaction of Immune and Cancer Cells by Daniela Spano, Massimo Zollo (auth.), Magdalena Klink (eds.)

By Daniela Spano, Massimo Zollo (auth.), Magdalena Klink (eds.)

The tumor setting is a dynamic community that incorporates melanoma cells, immune cells, fibroblasts, endothelial cells, extracellular matrix, cytokines and receptors. the purpose of this ebook is to summarize the function of those parts, particularly immune cells, in tumor suppression and/or development and describe intimately why tumor cells can continue to exist and unfold regardless of the antitumor reaction of immune cells. due to the fact that immunotherapy is an enticing method of melanoma treatment, this e-book additionally offers details at the major concepts: monoclonal antibodies and adaptive T telephone immunotherapy, with a spotlight on contemporary human scientific trials.

The ebook presents a cutting-edge, finished evaluation of immune cells in melanoma and is an fundamental source for scientists and doctors operating and/or lecturing within the box of melanoma study and immunology. ​

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Sample text

1 Epithelial Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Basement Membrane and Extracellular Matrix . . . . . . . . . . . . . . . . . . 3 TME: The Immune Components, Chronic Inflammation, Wound Healing, and Tumor Progression . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 EMT and TGF-β .

1 TGF-β Signaling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Osteopontin and EMT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . .

References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 27 28 28 28 31 36 37 39 42 42 Introduction The understanding of how normal cells transform into tumor cells and progress to invasive cancer and metastases continues to evolve. This expanding knowledge has inspired revision of the “hallmarks of cancer” that were established as the modern foundation for describing tumor progression [1].

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