Lymphocytes, Macrophages, and Cancer by D. Catovsky (auth.), Georges Mathé, Irène Florentin,
By D. Catovsky (auth.), Georges Mathé, Irène Florentin, Marie-Christine Simmler (eds.)
Fresh dwelling Bacillus Calmette-Guerin (BeG), injected i.v. into (C57BI/ 6xDBA/2)FI mice, activated peritoneal macrophages rendering them hugely cytotoxic for tumor cells in vitro. This cytotoxic task w~s already maximal 14 days after injection of one mg of BCG and remained good while three or five mg of BCG got. while spleen cells of the BCG-treat~d mice confirmed strongly depressed responses to the T-cell mitogens,PHA and Con A, regardless of the dose of BCG injected. The inhibitory impression was once proven to be mediated by way of suppressor cells which had features of macrophages for the reason that they can be got rid of by way of carbonyl iron and magnet remedy and have been adherent to plastic. unlike it used to be saw after injec tion of one mg of BCG, those suppressor cells on my own didn't account for the melancholy of T-cell re.sponses caused via better doses of BCG. Nylon-nonadherent cellphone populations got from spleen cells handled with three or five mg BCG partly retained the inhibitory task suggesting that suppressor T cells have been additionally precipitated after injection of excessive doses of BCG. by contrast, the responses to the B-cell mitogen LPS of unfractionated and macrophage-depleted spleen cells weren't affected or considerably more desirable counting on the dose of BCG injected.
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Extra resources for Lymphocytes, Macrophages, and Cancer
This necessity for prolonged contact may prove to be important for macrophage activation. This is suggested by comparing the prolonged effects in vivo of injection of casein, on the one hand, and C. parvum or other anaerobic coryneforms on the other. Both have short-term stimulating effects on macrophages. Both casein and C. parvum are chemotactic for macrophages and both induce a macrophage exudate 2-5 days after injection into the peritoneal cavity of the guinea-pig (49). However after casein-induction, these macrophages disappear from the peritoneal cavity soon afterwards.
The relevance of this mechanism to the microbicidal effect of activated macrophages is not known, especially since mature macrophages, at least in the mouse, are thought to be relatively poor in peroxidase activity (25). 2. Nonmicrobial Targets Activated macrophages appear to kill tumor cells by a nonphagocytic mechanism. Several authors have emphasized the need for a close contact between activated macrophages and target cells in order for the latter to be affected. However, a recent report by KELLER (26) suggests that, in addition to a contact-mediated effect, soluble factors produced by activated macrophages may decrease target-cell proliferation.
These last few oddities must be regarded as simply anecdo"tal for the moment. The results presented do not as they stand tell us much about the immunological status of the patients involved. They do tell us that in a variety of lymphoid neoplasias there are distortions of the normal patterns of T- and B-cell characteristics. The results also show that many of these lymphoid neoplasias are widely generalized diseases which can show consistent abnormalities in T- and B-cell pattern in whatever lymphoid organ is sampled.