Mechanisms in Myeloid Tumorigenesis 1988: Workshop at the by Archibald S. Perkins (auth.), Grace L. C. Shen-Ong Ph. D.,

By Archibald S. Perkins (auth.), Grace L. C. Shen-Ong Ph. D., Michael Potter M. D., Neal G. Copeland Ph. D. (eds.)

Contents: category of Myeloid Tumors.- particular Chromosomal Abnormalities in Human and Murine Myeloid Hematologic Malignancies.- Disruption of "Oncogenes" via Virus Insertion in Murine Myeloid Tumorigenesis.- Myeloid Leukemogenesis precipitated via Acute reworking Virus Constructs in In Vitro and In Vivo version Systems.- particular Genes fascinated about Myeloid Tumorigenesis.- Proposed Mechanisms in Myeloid Tumorigenesis.

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Extra resources for Mechanisms in Myeloid Tumorigenesis 1988: Workshop at the National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, March 22, 1988

Example text

Polycythemia Vera PV is the second most extensively studied MPD. Of untreated and treated PV patients (excluding patients analyzed only in the leukemic blast phase), one-fourth (23%) have chromosomally abnormal clones in their initial analysis. Abnormalities are less common in untreated patients than in those who have been treated with cytotoxic agents prior to their first cytogenetic examination (14% versus 39%, respectively). The incidence of abnormal clones is even higher (85%) in treated PV patients whose disease has transformed to a leukemic phase.

REFERENCES Atkin NB (1985) Antionoogenes. Lancet 11: 1189-1190. JI, Sachs L ( 1977 ) 01rar0scme mapping of the genes that centrol differentiaticn and malignancy in myeloid leukemic cells. Proc Natl Acad Sci USA 74: 253-257. Azumi Brenner B, Carter A, Sharon R, Tatarsky I (1984) Acute leukemia following chem:>therapy and radiation therapy. A rep:>rt of 15 cases. Oncology 41: 83-87. 40 De Vita V, Serpick A, CarIxlne P (1970) Ccmbination cherotherapy in the treatment of advanced Hodgkin's disease.

In: King RA, Rotter JJ, Motulsky AG (eds) The Genetic Basis of Common Diseases. Oxford University Press, New York, in press Mitelman F (1988) Catalog of Chromosome Aberrations in Cancer (3rd edition). Alan R. Liss, New York, p 1 Rowley JD (1984) Biological implications of consistent chromosome rearrangements in leukemia and lymphoma. Cancer Res 44:3159-3165 Second MIC Cooperative study Group (1988) Morphologic, immunologic and cytogenetic (MIC) working classification of the acute myeloid 1eukaemias.

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