The Mouse in Animal Genetics And Breeding Research by Eugene J Eisen

By Eugene J Eisen

The sequencing of the mouse genome has put the mouse entrance and middle because the most vital mammalian genetics version. although, no fresh quantity has specified the genetic contributions the mouse has made around the spectrum of the existence sciences; this publication goals to fill that vacuum. Mouse genetics study has made huge, immense contributions to the knowledge of easy genetics, human genetics, and farm animals genetics and breeding. The wide-ranging themes within the publication contain the mouse genome sequencing attempt, molecular dissection of quantitative features, embryo biotechnology, ENU mutagenesis, and genetics of illness resistance, and feature been written through specialists of their respective fields.

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Effects of Maternal Age Both early motherhood (immediately after puberty onset) and late motherhood (near menopause) can negatively impact offspring growth and increase disease incidence. 53 Eisen54 found that females bred soon after puberty onset showed decreased litter size, littering rate, and pup birth weight with increased pup mortality compared to females bred at older ages. 56" 58 The reduced prenatal growth may be due to a decrease in uterine and placental quality affecting nutrients received by the fetus59 while decreased postnatal growth may be due to decrease in quality and quantity of lactation.

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Pomp. 2004. A large-sample QTL study in mice: I. Growth. Mamm. Genome 15:83-99. 77. Hayes, B. E. Goddard. 2001. The distribution of the effects of genes affecting quantitative traits in livestock. Genet. Sel. Evol. 33:209-229. 78. Robertson, A. 1967. The nature of quantitative genetic variation. In: Heritage from Mendel ed. A. Brink, pp. 265-280. Wisconsin University Press, Madison. CHAPTER 3 MATERNAL EFFECTS, GENOMIC IMPRINTING AND EVOLUTION Jhondra Funk-Keenan1'3 and William R. Atchley1'2'4 2 'Department of Genetics Center for Computational Biology North Carolina State University Raleigh, NC, USA 3 jfunkk @ncsu.

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