Multiple Drug Resistance in Cancer 2: Molecular, Cellular by Irene Bosch, James M. Croop MD, PhD (auth.), Martin Clynes

By Irene Bosch, James M. Croop MD, PhD (auth.), Martin Clynes (eds.)

Resistance to chemotherapy, and particularly multi-drug resistance, represents an important barrier to the profitable therapy of melanoma. This multi-author quantity brings jointly a variety of up to date experiences on diverse features of our wisdom of drug-resistance mechanisms, written by way of specialists within the diversified parts. specific cognizance is paid to lately chanced on mechanisms with regards to oncogene expression and specifically to proteins all for legislation and execution of apoptosis. different very important issues lined contain DNA fix, topoisomerases, mobile cycle keep an eye on, oxygenation and vascularisation of tumours, LRP, intermediate filament proteins and low-level resistance. contemporary advancements in realizing the function of efflux pumps (P-170, MRP) in multi-drug resistance also are reviewed. This e-book could be worthwhile to clinicians and scientists operating within the parts of chemotherapy, drug resistance, DNA fix and apoptosis research.

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Gros P, Croop J, Roninson I, Varshavsky A and Housman DE (1986c) Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells. Proc N atl Acad Sci 83: 337-341. Gros P, Dhir. R, Croop J and Talbot F (1991) A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdrJ drug efflux pumps. Proc Natl Acad Sci 88: 7289-7293. Gros P, Raymond M, Bell J and Housman D (1988) Cloning and characterization of a second member of the mouse mdr gene family.

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