Multiple Drug Resistance in Cancer 2: Molecular, Cellular by Irene Bosch, James M. Croop MD, PhD (auth.), Martin Clynes

By Irene Bosch, James M. Croop MD, PhD (auth.), Martin Clynes (eds.)

Resistance to chemotherapy, and particularly multi-drug resistance, represents an important barrier to the profitable therapy of melanoma. This multi-author quantity brings jointly a variety of up to date experiences on diverse features of our wisdom of drug-resistance mechanisms, written by way of specialists within the diversified parts. specific cognizance is paid to lately chanced on mechanisms with regards to oncogene expression and specifically to proteins all for legislation and execution of apoptosis. different very important issues lined contain DNA fix, topoisomerases, mobile cycle keep an eye on, oxygenation and vascularisation of tumours, LRP, intermediate filament proteins and low-level resistance. contemporary advancements in realizing the function of efflux pumps (P-170, MRP) in multi-drug resistance also are reviewed. This e-book could be worthwhile to clinicians and scientists operating within the parts of chemotherapy, drug resistance, DNA fix and apoptosis research.

Show description

Read Online or Download Multiple Drug Resistance in Cancer 2: Molecular, Cellular and Clinical Aspects PDF

Best cancer books

Cancer: Basic Science and Clinical Aspects

This ahead having a look melanoma biology booklet appeals to a panoramic viewers. Introductory chapters that offer the molecular, mobile, and genetic details had to understand the cloth of the following chapters carry unprepared scholars on top of things for the remainder of the booklet and function an invaluable refresher for people with earlier biology history.


This consultant is for breast melanoma sufferers, their spouses and kids, and their households, co-workers, and buddies. the writer hopes to respond to the sensible, way of life questions that each breast melanoma sufferer or family member has. The e-book offers details, options, assistance, and idea for every little thing from that first biopsy to the five-year check-up.

Gastrointestinal Cancer (M.D. Anderson Cancer Care Series)

Gastrointestinal melanoma contains melanoma of the digestive approach - the esophagus, colon, rectum, anus, liver, pancreas, and different digestive organs. Taken as a complete, there are an predicted 250,600 new circumstances within the US. Colon and rectum melanoma is the 3rd best reason behind melanoma and melanoma deaths within the US.

Camptothecins in Cancer Therapy (Cancer Drug Discovery and Development)

A severe evaluate our present knowing of camptothecins, their shortcomings, and of the chances for bettering their scientific functionality. The authors talk about new camptothecin analog improvement, drug supply matters for optimizing their anticancer task, and their capability use in numerous various cancers.

Additional info for Multiple Drug Resistance in Cancer 2: Molecular, Cellular and Clinical Aspects

Sample text

Gros P, Croop J, Roninson I, Varshavsky A and Housman DE (1986c) Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells. Proc N atl Acad Sci 83: 337-341. Gros P, Dhir. R, Croop J and Talbot F (1991) A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdrJ drug efflux pumps. Proc Natl Acad Sci 88: 7289-7293. Gros P, Raymond M, Bell J and Housman D (1988) Cloning and characterization of a second member of the mouse mdr gene family.

Buschman E, Arceci R, Croop J, Mingxin C, Arias I, Housman D and Gros P (1992) Isoform specific antibodies identify the bilie canalicular membrane as the primary site of expression of the Pglycoprotein encoded by mouse mdr2. J BioI Chern 267: 1809318099. Callahan HL and Beverley S (1991) Heavy metal resistance: a new role for P-glycoproteins in Leishmania. J BioI Chern 266: 18427-18430. Castillo G, Shen HJ and Horwitz SB (1995) A homologue of the mammalian multidrug resistance gene (mdr) is functionally expressed in the intestine of Xenopus laevis.

Ouellette M and Borst P (1995) New mechanisms of drug resistance in parasitic protozoa. Ann Rev Micro 49: 427-460. Ouellette M, Fase-Fowler F and Borst P (1990) The amplified H circle of methotrexate-resistant Leishmania tarentolae contains a novel P-glycoprotein gene. Embo J 9: 1027-1033. Ouellette M, Hettema E, Wust D, F. F-F and Borst P (1991) Direct and inverted DNA repeats associated with P-glycoprotein gene amplification in drug resistant Leishmania. Embo J 10: 10091016. Paulusma CC, Bosma PJ, Zaman GJR, Bakker CTM, Otter M, Scheffer GL, Scheper RJ, Borst P and Elferink R (1996) Congenital Jaundice In Rats With A Mutation In A Multidrug Resistance-Associated Protein Gene.

Download PDF sample

Rated 4.81 of 5 – based on 24 votes