Narcolepsy and Hypersomnia by Bassetti Claudio, Michel Billiard, Emmanuel Mignot

By Bassetti Claudio, Michel Billiard, Emmanuel Mignot

Compiled via a world team of greater than forty authors, this reference booklet offers a fascinating and entire evaluation of the most important issues and key matters linked to narcolepsy and hypersomnia. Spanning the most recent advances within the box, this resource covers present diagnostic techniques, genetic advancements, explorations of animal types, new definitions and standards, and more desirable epidemiological surveys to mirror the explosion of study during this evolving technology.

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Ann Med Psy 1848; 11:26– 40. 13. Binns E. The anatomy of sleep; or the art of procuring a sound and refreshing slumber at will. London: J Churchill; 1842. 14. Mitchell SW. On some disorders of sleep. Va Med Monthly 1876; 2:769– 781. 15. Blocq P. Semeiology of sleep. Brain 1891; 14:112–126. 16. Vogel G. Studies in psychophysiology of dreams III. The dreams of narcolepsy. Archives of general psychiatry 1960; 3:421– 428. 17. Rubboli G, d’Orsi G, Zaniboni A, et al. A video-polygraphic analysis of the cataplectic attack.

Further trials with apomorphine had no efficacy. Interestingly, he tried to give strychnine, which is now known to block post-synaptic glycinergic transmission, in particular at the spinal motor neuron, where it could antagonize REM sleep-induced atonia, but obtained only a transitory effect. Dr. Ge´lineau finally recommended to treat the narcoleptic sleepiness with caffeine [as originally suggested by Willis in 1672 (21)], despite the fact it was of little benefit in his only genuine case. A more potent treatment (ephedrine sulfate) than caffeine was suggested by Janota and Daniels about 50 years later (21).

Karl Friedrich Otto Westphal, born in 1833 in Berlin, is the son of a well-known and wealthy physician. After a European medical education that included studies in Germany, Switzerland, and France, he joined the smallpox clinic at the Berlin Charite´ hospital to rise to become full professor of Neurology and Psychiatry (Nervenkraknheiten) in 1865, where he trained a number of well-known physicians, including Arnold Pick and Carl Wernicke. His achievements are numerous and include the first descriptions of agoraphobia; the first description of periodic paralysis; the report of a relationship between tabes dorsalis and general paralysis of the insane, prefiguring the syphilis connection; work on pseudosclerosis; and (in 1875) the first description of the deep tendon reflex.

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