Neuropharmacology. Studies of Narcotic Drugs by P. B. Bradley

By P. B. Bradley

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Accumbens 0-64 2-8 30 >100 > 10 >20 1-6 3 22 > 100 >10 >20 Tyrosine hydroxylase activity was measured in tissue homogenates prepared as described by ZIVKOVIC et al. ( 1 9 7 4 ) . The enzyme activity was measured with saturating concentrations of tyrosine and with 0-3 mM pteridine cofactor (dimethyltetrahydropteridine). 932 A. CARENZI, D . L . CHENEY, E. COSTA, A. GUIDOTTI and G . RACAGNI Table 3. Action of opiates, ( + )-amphetamine and antipsychotics on the stimulation of the adenyl cyclase from rat striatum and nucleus accumbens by D A I C 50 (M) Striatum Drug Clozapine Haloperidol ( + )-Amphetamine Morphine Viminol R 2 4 χ 10 N.

Effect of tricyclic antidepressant and chloropromazine on brain catecholamine system. In : Proceedings of the International Symposium on Antidepressant Drugs (GARATTINI, S. and BURKES, Μ. N . ) pp. 28-34. Excerpta Medica Foundation, N e w York. ROTH, R. , WALTERS, J. , M U R R I N , L . C. and MORGENROTH, V. H. (1975). D o p a m i n e neurons: role of impulse flow and presynaptic receptors in the regulation of tyrosine hydroxylase. In: Pre and Postsynaptic Receptors (USDIN, E. ) pp. 5 ^ 6 . Marcel Dekker, N e w York.

1 8 : 412. PATON, W . D . and VIZI, E. S . (1969). The inhibitory action of noradrenaline and adrenaline on acetylcholine output by guinea pig ileum longitudinal muscle strip. Br. J. Pharmac. 3 5 : 10-28. PORSZÂSZ, J. and HERR, F. (1950). Analgetikus hatâs viszgâlata egéren. Kisérl. Orvostud. 2 : 295-306. (In Hungarian). SAELENS, J. K . , G R A N A T , F. R . and SAWYER, W . K . (1971). The mouse jumping test - a simple screening method to estimate the physical dependence capacity of analgesics.

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