NPY Family of Peptides in Neurobiology, Cardiovascular and by Zofia Zukowska, Giora Z. Feuerstein

By Zofia Zukowska, Giora Z. Feuerstein

The NPY-family of peptides encompasses numerous teams of neurotransmitters and hormones, which exert diversified organic and pathological activities that undergo on all significant important platforms. This ebook is a distinct compilation of the latest breakthroughs in NPY/PYY neurobiology, cardiovascular and metabolic problems. The identity of a number of receptors for the individuals of the NPY and PYY relatives of peptides offers new possibilities for discovery of particular NPY antagonists and agonists that experience colossal scientific strength. the popularity of the function of NPY in stimulation of meals consumption has already led to discovery of effective and selective NPY receptor Y-5 antagonists, that are in scientific improvement for weight problems. NPY Y1 receptor antagonists are exact for cardiovascular symptoms. learn into the a number of features of NPY and its receptors in neurological and affective issues can also be actively pursued. The chapters during this publication are written by way of across the world popular specialists with the target to synthesize prime options and information in aid for translational medicine.

The perfect supplement to this quantity is the publication NPY relations of Peptides in Immune issues, irritation, Angiogenesis, and Cancer, lately released through a similar editors within the Birkhäuser e-book sequence Progress in irritation Research. either volumes jointly supply a complete assessment of the NPY kinfolk of peptides.

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An overview of neuropeptide Y: pharmacology to molecular biology and receptor localization 31 receptor sub-type. Mol Brain Res 26: 320–324 165 Hirabayashi A, Nishiwaki K, Shimada Y, Ishikawa N (1996) Role of neuropeptide Y and its receptor subtypes in neurogenic pulmonary edema. Eur J Pharmacol 296: 297–305 166 Wahlestedt C, Regunathan S, Reis DJ (1992) Identification of cultured cells selectively expressing Y1-, Y2-, or Y3-type receptors for neuropeptide Y/peptide YY. Life Sci 50: L7–12 167 Zhang P, Zheng J, Vorce RL, Hexum TD (2000) Identification of an NPY–Y1 receptor subtype in bovine chromaffin cells.

An overview of neuropeptide Y: pharmacology to molecular biology and receptor localization 31 receptor sub-type. Mol Brain Res 26: 320–324 165 Hirabayashi A, Nishiwaki K, Shimada Y, Ishikawa N (1996) Role of neuropeptide Y and its receptor subtypes in neurogenic pulmonary edema. Eur J Pharmacol 296: 297–305 166 Wahlestedt C, Regunathan S, Reis DJ (1992) Identification of cultured cells selectively expressing Y1-, Y2-, or Y3-type receptors for neuropeptide Y/peptide YY. Life Sci 50: L7–12 167 Zhang P, Zheng J, Vorce RL, Hexum TD (2000) Identification of an NPY–Y1 receptor subtype in bovine chromaffin cells.

J Biol Chem 271: 16435–16438 96 Burkhoff A, Linemeyer DL, Salon JA (1998) Distribution of a novel hypothalamic neuropeptide Y receptor gene and it’s absence in rat. Mol Brain Res 53: 311–316 97 Walker P, Munoz M, Martinez R, Peitsch MC (1994) Acidic residues in extracellular loops of the human Y1 neuropeptide Y receptor are essential for ligand binding. J Biol Chem 269: 2863–2869 98 Sautel M, Martinez R, Munoz M, Peitsch MC, Beck-Sickinger AG, Walker P (1995) Role of a hydrophobic pocket of the human Y1 neuropeptide Y receptor in ligand binding.

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