Ovarian Cancer by Jeffrey M. Trent (auth.), David S. Alberts, Earl A. Surwit
By Jeffrey M. Trent (auth.), David S. Alberts, Earl A. Surwit (eds.)
Where do you start to appear for a up to date, authoritative article at the diag nosis or administration of a selected malignancy? The few basic oncology textbooks are mostly old-fashioned. unmarried papers in really good journals are informative yet seldom accomplished; those are extra usually initial reviews on a really constrained variety of sufferers. yes basic journals fre quently post stable in-depth studies of melanoma subject matters, and released sym posium lectures are usually the easiest overviews on hand. regrettably, those studies and vitamins look sporadically, and the reader can by no means determine while a subject matter of specific curiosity can be coated. melanoma remedy and study is a chain of authoritative volumes which target to fulfill this want. it's an try and identify a serious mass of oncology literature masking nearly all oncology subject matters, revised often to maintain the insurance brand new, simply to be had on a unmarried library shelf or through a unmarried own subscription. now we have approached the matter within the following model. First, via di viding the oncology literature into particular subdivisions similar to lung melanoma, genitourinary melanoma, pediatric oncology, and so on. moment, by way of asking eminent gurus in each one of those components to edit a quantity at the particular subject on an annual or biannual foundation. each one subject and tumor sort is roofed in a quantity showing often and predictably, discussing present analysis, staging, markers, all kinds of therapy modalities, simple biology, and more.
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10. II. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. ovarian tumors of serous, endometrioid and clear cell types. Am J Clin Path 79: 98-104, 1983. Buick RN, Pullano R, Knapp RC, Urbach GI, Chang PL, Bast RC Jr: Classification of ovarian tumor associated antigens on the basis of distribution on cell populations undergoing differentiation. Proc Amer Assoc Cancer Res 25: 40, (abstr), 1984. Masuho Y, Zalutsky M, Knapp RC, Bast RC Jr: Interaction of monoclonal antibodies with cell surface antigens of human ovarian carcinomas.
CA 125 is associated with coelomic epithelium and amnion during embryonic development . Traces of CA 125 are found in adult tissues derived from coelomic epithelium, including the pleura, peritoneum and pericardium, as well as the epithelial cells lining the fallopian tube, endometrium and endocervix . CA 125 has been detected in endocervical mucus consistent with the physiological secretion of the antigen. Significantly, CA 125 is also associated with more than 80% of non mucinous epithelial ovarian carcinomas [3, 5].
Conclusions Development of the monoclonal technology has permitted the production of a variety of reagents which bind to antigenic determinants associated with epithelial ovarian carcinomas. None is specific for ovarian carcinoma, but several may prove valuable, particularly for monitoring response to treatment. The CA 125 assay may provide a useful marker for monitoring the course of epithelial ovarian cancer and deserves further evaluation in early detection of the disease. A number of monoclonal antibodies recognize carbohydrate determinants associated with high molecular weight mucinlike molecules.