Physics Reports vol.92

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Mutations in selenoprotein N were identified in patients with either rigid spine muscular dystrophy (RSMD1), multiminicore disease (MmD), Mallory body-like desmin-related myopathy (MBDRM) or myopathy with congenital fiber-type disproportion (CFTD). , 2001). , 2011). 5 Iodothyronine Deiodinases Three different deiodinases (deiodinase type I–III, Dio1–3) are responsible for activation and inactivation of thyroid hormones, respectively (Schomburg and Kohrle, 2008; Dentice and Salvatore, 2011). The thyroid gland mostly secrets the inactive prohormone T4 (3,3′,5,5′-tetraiodothyronine, thyroxine) which is converted into the active T3 (3,3′,5-triiodothyronine) by the action of Dio2 or inactivated to rT3 (reverse 3,3′,5′-triiodothyronine) by Dio3 in the periphery.

2007). Selenides are the most prevalent organoselenium compounds. They may be obtained by synthetic methods or occur as byproducts of other reactions. Selenides are generally stable compounds that can be alkylated to afford selenonium salts or oxidized to either the corresponding selenoxides or selenones. 3 Selenium in Soil and Foods The content of selenium in foods varies according to geographical origin both within and between countries (Navarro-Alarcon and Cabrera-Vique, 2008). Selenium levels in plants are directly affected by selenium content in the soil.

2012. Selenocysteine insertion sequence (SECIS)-binding protein 2 alters conformational dynamics of residues involved in tRNA accommodation in 80S ribosomes. Journal of Biological Chemistry. 287: 10664–10673. , Kinzy, S. A. and Copeland, P. , 2007. The L7Ae RNA binding motif is a multifunctional domain required for the ribosome-dependent Sec incorporation activity of Sec insertion sequence binding protein 2. Molecular and Cellular Biology. 27: 6350–6360. , Amma, L. , Faris, J. , Kelley, M. W.

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