Platinum Coordination Complexes in Cancer Chemotherapy: by J. Reedijk (auth.), Miles P. Hacker, Evan B. Douple, Irwin
By J. Reedijk (auth.), Miles P. Hacker, Evan B. Douple, Irwin H. Krakoff (eds.)
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Extra info for Platinum Coordination Complexes in Cancer Chemotherapy: Proceedings of the Fourth International Symposium on Platinum Coordination Complexes in Cancer Chemotherapy convened in Burlington, Vermont by the Vermont Regional Cancer Center and the Norris Cotton
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The documented specificity of the antibody for DNA from cultured cells and mouse acites fluid treated with cis-[Pt(NH3)2CI2] strongly implies that this adduct is also formed in vivo. The observation that the ELISA profile of in vivo DNA samples show less efficient antibody binding than for immunogen DNA suggests a more heterogeneous in vivo adduct population. 23 cis- DDP- DNA COMPETITIVE ELISA In IIltro • "S- DOP-DNA 100 • IrGnS-DDP-DNA o Cis-DDP-poly dG"poIy dC I:> ClS- DOP-poIy dG" dC 40 20 100 fmoles PI in z 0 • cis- DDP- DNA 100 "CIS - COP - DNA (culturld LI210 ellis) oeil-DDP-DNA (alcil..
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