Port-Site and Wound Recurrences in Cancer Surgery: Incidence by A. Tannapfel, C. Wittekind (auth.), Marc A. Reymond M.D., H.

By A. Tannapfel, C. Wittekind (auth.), Marc A. Reymond M.D., H. Jaap Bonjer M.D., Ph.D., Ferdinand Köckerling M.D. (eds.)

During the previous nine years, experiences of 'port-site' deposits following laparoscopic surgical procedure for malignancy, specially laparoscopic resection of colonic melanoma, have forged a shadow at the knowledge of the laparoscopic procedure within the surgical guy­ agement in sufferers with melanoma. these stories of port-site deposits, a few ninety circumstances suggested within the literature as much as 1999, have opened a 'can of worms' and highlighted the shortage of our wisdom on melanoma cellphone migration from reliable tu­ mors and the standards that underlie their profitable implantation in surgical wounds either within the presence and shortage of a good strain pneumoperito­ neum. The jury is out even when it comes to the impression of the therapeutic surgical entry wound - do the biochemical and mobile fix methods and the linked development components increase or hinder implantation of exfoliated manageable tumor cells? regardless of the resolution to this question, it's transparent that tumor cells do implant in therapeutic surgical wounds and the most important query is whether or not this can be facilitated by way of lap­ aroscopic surgical procedure with CO pneumoperitoneum in comparison to the conventional 2 surgical publicity. it really is recognized that tumors shed malignant cells into the blood movement, the peritoneal hollow space and when it comes to hole organs, intraluminally. both there's strong proof that surgical and instrumental manipulation of tumors result in exfoliation of plausible tumor cells.

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Extra resources for Port-Site and Wound Recurrences in Cancer Surgery: Incidence - Pathogenesis - Prevention

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1996; Lord et al. 1%, closer to the incidence found in open surgery. The range of follow- up in these studies has been short, however, ranging from 12 months (Vukasin et ai. 1996) to 30 - 36 months (Franklin et al. 1996). 1. Prospective randomized data on the incidence of port -site recurrences Author a Year :-lo. lap opera · No. recur· Median rences follow . up lions ('Yo) (range) Lacy et al. 5 months (1-12) Stage et al. 1997 15 0(0%) 14 month (7 - 19) "Milsom ct al. 5 - 46) Two local abdominal recurrences were seen in the open group, both in the setting of disseminated disease 6 Port-Site Recurrences in Colon and Rectal Cancers: Randomized Studies Judging from these randomized prospective studies, at least in the short term, there is no increased risk of port-site recurrence after laparoscopic resection of colorectal cancers.

Such rare umbilical metastases from intraabdominal tumors are known as "Sister Mary Joseph's nodules" and can be the first sign of malignant disease in a patient (Khan and Cook 1997). Though its pathogenesis may be different from the pathogenesis of port-site metastases, the Sister Mary Joseph's nodule in this patient illustrated the avidity of gallbladder cancer cells for the abdominal wall. In this laparoscopic era, thorough ultrasonographic evaluation of the gallbladder is mandatory to prevent any dismal consequences of laparoscopic cholecystectomy.

Strain A mice do not produce antitumor response to TBJ-NB. The tumor does not produce class I major histocompatibility antigens (MHCI) and is resistant to natural killermediated (NK) tumor killing. It is considered minimally immunogenic. 2) Colon Cancer (CC531) CC531 is a 1,2 dimethylhydrazine-induced, moderately differentiated adenocarcinoma of the rat colon (Martin et al. 1973). The tumor is syngeneic to WAG rats and transplantable when injected in RPMI 1640 with 5% fetal calf serum and penicillin/streptomycin medium.

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