Precision Molecular Pathology of Breast Cancer by Ashraf Khan, Ian O. Ellis, Andrew M. Hanby, Ediz F. Cosar,

By Ashraf Khan, Ian O. Ellis, Andrew M. Hanby, Ediz F. Cosar, Emad A. Rakha, Dina Kandil

This quantity offers a finished evaluate of the molecular mechanisms fascinated by precancerous lesions and benign and malignant breast tumors. Given the complicated molecular pathways in breast melanoma biology, the publication simplifies those complicated mechanisms and highlights the sensible matters very important for day-by-day perform. Sections are based to study breast carcinogenesis and the position of familial predisposition and stem cells in initiation and development of breast melanoma. In-depth chapters current morphologic and molecular correlations in precancerous and malignant breast lesions, whereas outlining hugely useful matters which are in perform this day in breast pathology, comparable to overview of estrogen, progesterone receptors, and HER-2.

Written through specialists within the box, Precision Molecular Pathology of Breast Cancer is a beneficial source that covers the present perform of breast pathology and appears into the long run with an emphasis at the molecular foundation of breast cancer.

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Walavalkar et al. Nielsen TO, Hsu FD, Jensen K, Cheang M, Karaca G, Hu Z, et al. Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin Cancer Res. 2004;10(16):5367–74. Rakha EA, Elsheikh SE, Aleskandarany MA, Habashi HO, Green AR, Powe DG, et al. Triple-negative breast cancer: distinguishing between basal and nonbasal subtypes. Clin Cancer Res. 2009;15(7):2302–10. Jensen RB, et al. Purified human BRCA2 stimulates RAD51- mediated recombination.

2000;6(3):782–9. Lakhani SR, Jacquemier J, Sloane JP, Gusterson BA, Anderson TJ, et al. Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations. J Natl Cancer Inst. 1998;90(15):1138–45. Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, et al. Molecular portraits of human breast tumours. Nature. 2000;406(6797):747–52. Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications.

Two-Dimensional (2D) Cell Line Models Types and Techniques Over the past century, several breast cancer cell lines have been established. These have proven to be valuable experimental tools with many examples of research carried out with breast cancer cell lines leading to the production of new therapies 3 Modelling the Molecular Pathology of Breast Cancer Initiation 41 for patient benefit. Studies have shown that the molecular subtypes of breast cancer outlined by Perou et al. [13] can be also delineated in panels of breast cancer cell lines.

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