Prefrontal cortex : from synaptic plasticity to cognition by Satoru Otani

By Satoru Otani

This quantity, Prefrontal Cortex: from Synaptic Plasticity to Cognition, is an interdisciplinary method of signify the functionality of the anterior section of the frontal lobe in rodents and human and non-human primates. the categorical themes mentioned within the chapters of this quantity are purposefully varied: they vary from membrane houses of prefrontal neurons to cognitive psychology. however, this quantity must never be considered as a trifling selection of writings with the various sub-themes. As you can find, chapters usually vigorously surround domain names of the prefrontal box in attempt to supply an enormous photograph. that's truly what we tried to do during this quantity. On one hand, we've got amassed wisdom at the houses of neurons and synapses within the prefrontal cortex in addition to the activities of serious neuromodulators resembling dopamine. nevertheless, behavioral and cognitive neurosciences have all started to bare the interesting position of the prefrontal cortex in such psychological procedures as operating reminiscence, realization switching and rule following, and long term reminiscence. keep in mind that, our final target as neurobiologists is to understand what dating there's among those mobile and cognitive procedures. This quantity is intended to function a complete creation in the direction of that aim. Readers can be trained, for instance, of the way plasticity of prefrontal neurons is regulated, the way it is desirous about convinced cognitive procedures in rodents, and the way the rodent types can observe to the primates.

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Behav Biol 10:329-343. Kolb B (1974b) Prefrontal lesions alter eating and hoarding behavior in rats. Physiol Behav 12:507-511. Kolb B (1974c) Some tests of response habituation in rats with prefrontal lesions. Can J Psychol 28:260-267. Kolb B (1974d) The social behavior of rats with chronic prefrontal lesions. J Comp Physiol Psychol 87:466-474. Kolb B (1984) Functions of the frontal cortex of the rat: A comparative review. Brain Res Rev 8:65-98. Kolb B (1990) Animal models for human PFC-related disorders.

On such tasks, PFC patients commit repeated errors that they are consciously aware of and that they can report, but cannot use to update behavior (Milner, 1963; Konow and Pribram, 1970). A classic example of this is observed in PFC patients with the Wisconsin Card Sorting task (Milner, 1963). This task requires subjects to formulate a card sorting strategy based on feedback from an experimenter. PFC-damaged patients are able to deduce, remember, and verbalize the correct sorting strategy to the experimenter, but are unable to 36 Seamans alter their sorting strategy based on this knowledge.

Given that the reward value of many events, including drugs, appears to wane with age, it would not be surprising to find age-related differences in reward-induced synaptic reorganization. Finally, how do reward-induced synaptic changes interact with other experience-dependent changes? g. , 2003c)? g. g. Kimura, 1999) and rhesus monkeys (Clark and Goldman-Rakic, 1989). This leads to the possibility that there might be sex-related differences in the structure of cells in the mPFC and/or OFC. There are.

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