Primary Liver Cancer in Japan by Kunio Okuda (auth.), Takayoshi Tobe M. D., Haruo Kameda,

By Kunio Okuda (auth.), Takayoshi Tobe M. D., Haruo Kameda, Masahiko Okudaira, Masao Ohto, Yasuo Endo, Michio Mito, Eizo Okamoto, Kyuichi Tanikawa, Masamichi Kojiro (eds.)

Hepatocellular carcinoma (HCC) is usual within the some distance East and South Africa, yet is unusual within the usa and Europe. The great event of the East, which has ended in marked development within the analysis of sufferers with HCC, is made on hand to researchers world wide during this monograph. The ebook is predicated on an incredible quantity of information that has been accrued and analyzed by way of the Liver melanoma research team of Japan. the knowledge stems from a survey on HCC in Japan given that 1965 and comprises info from greater than 30,000 sufferers in regards to age distribution, earlier scientific heritage, diagnostic strategies, frequency of HBV-associated antigens and antibodies, surgical and conservative remedies, gross anatomical and histological good points of the tumors, pathology of the noncancerous parts, far-off metastasis, and survival price. this knowledge is an enormous contribution to our knowing of the epidemiology, pathology, and the newest advancements of the molecular biology and scientific difficulties of basic liver cancer.

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Eggel H (1901) Uber das primare Carcinoma der Leber. Beitr. Pathol Anat Allg Pathol 30:506-604 4. Nakashima T, Kojiro M (1987) Hepatocellular carcinoma: An atlas of its pathology SpringerVerlag, Tokyo 5. Arakawa M, Kage M, Isomura T, Motoyama F, Kubo Y, Nakayama T (1982) Pathomorphological studies on hepatocellular carcinoma (HCC): Seven cases of HCC with an extrahepatic tumor growth"pedunculated hepatoma" Acta Hepatol Jpn 23:942-948 6. Horie Y, Kato S, Yoshida H, Imaoka T, Suou T, Hirayama C (1983) Pedunculated hepatocellular carcinoma: Report of three cases and review of literature.

Hepatic lobes replaced by carcinoma are usually not enlarged. Nodular type of CCC is characterized by one or mUltiple nodules of the tumor (Fig. 1b). They are usually round and the sizes are variable. A majority of these nodules may correspond to the intrahepatic metastases of CCC, and the largest nodule is generally regarded as primary. A diffuse type is rare, and is characterized by numerous tumor foci with unclear borders [5]. This classification is applicable to most cases of CCC, especially advanced CCC, though an overlapping of these three types is not infrequent.

8). These results suggest that some HCCs progress from the early to advanced stage through nodule-in-nodule lesions. Histologically, early HCCs were always very well differentiated, corresponding to grade I carcinoma according to Edmondson and Steiner's classification. In some of these HCCs (about AdHCC eAdHCC eHCC Fig. 8. Macroscopic types of small HCCs and tumor sizes. AdHCC, Advanced HCC; eHCC, Early HCC; eAdHCC, Nodule-in-nodule lesion with components of early HCC and advanced HCC 30%), a focal area of moderately differentiated HCC was also detected.

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