RNA and Cancer by Ignacio E. Schor, Luciana I. Gómez Acuña, Alberto R.

By Ignacio E. Schor, Luciana I. Gómez Acuña, Alberto R. Kornblihtt (auth.), Jane Y. Wu (eds.)

Accumulating facts helps the function of defects in post-transcriptional gene rules within the improvement of melanoma. RNA and melanoma examines the new advances in our figuring out of post-transcriptional gene law, particularly RNA processing and its position in melanoma improvement and therapy. a selected concentration is mRNA splicing, yet different subject matters comparable to microRNAs, mRNA balance, the perinucleolar compartment, and oligonucleotide therapeutics also are coated intimately. All chapters were written via the world over popular specialists. The booklet is meant for all with an curiosity in gene legislation and melanoma biology, and particularly for these in some way engaged on RNA biology, together with clinicians and clinical scholars. it really is was hoping that it'll stimulate additional leading edge learn collaborations among RNA biologists and melanoma researchers to the advantage of patients.

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For example, an intronic interval was found in intron 2 of the IFI27 gene. Further analysis indicates that this intragenic interval is part of a novel transcript with a long exon 2 that ends within the intron 2 of the standard, longer transcript (Fig. 3b). Another interval was found in the intron of FOXA1 gene, which is shown to be an alternative exon (Fig. 3c). IFI27, interferon alpha-inducible protein 27, is up-regulated in a number of epithelial cancers, although its association with breast cancer is less clear [57, 58].

French PJ, Peeters J, Horsman S et al (2007) Identification of differentially regulated splice variants and novel exons in glial brain tumors using exon expression arrays. Cancer Res 67:5635–5642 27. Cheung HC, Baggerly KA, Tsavachidis S et al (2008) Global analysis of aberrant pre-mRNA splicing in glioblastoma using exon expression arrays. BMC Genomics 9:216 28. Hallegger M, Llorian M, Smith CW (2010) Alternative splicing: global insights. The FEBS J 277:856–866 29. Lapuk A, Marr H, Jakkula L et al (2010) Exon-level microarray analyses identify alternative splicing programs in breast cancer.

The ENCODE tiling array has *750,000 25-mer PM and MM oligo probes, spaced at 21-bp intervals. 7 % of the nucleotides represented on the arrays, with 63 % of the TxFrags residing in intronic or intergenic regions. By a combination of 50 RACE and tiling array hybridization, more than 60 % of the annotated protein-coding genes show evidence of new alternative exons in their introns, and 68 % exhibit a potential new transcription start site upstream of their first annotated exon [45]. The distal 50 exons often overlap with adjacent genes, thus creating chimeric transcripts.

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