RNA Tumor Viruses, Oncogenes, Human Cancer and AIDS: On the by T. S. Papas, N. C. Kan, D. K. Watson, J. A. Lautenberger, C.

By T. S. Papas, N. C. Kan, D. K. Watson, J. A. Lautenberger, C. Flordellis, K. P. Samuel (auth.), Philip Furmanski, Jean Carol Hager, Marvin A. Rich (eds.)

We stand at the present time at the threshold of a brand new knowing of melanoma. basically throughout the strong instruments of molecular biology, unified hypotheses explaining the origins of the sickness are rising and quickly being demonstrated. This quantity, which offers the most recent findings from laboratories during the international at the position of RNA tumor viruses in melanoma, is a party of those achievements and a prediction of additional development major eventually to the regulate of the ailment. it is necessary during this context to remember the ordinary background or lifestyles cycle of RNA melanoma virology. From the earliest days of the technology, while viruses have been first well-known as distinctive biologic brokers of etiologic importance, their function in melanoma used to be proposed and hotly debated. The serious early discoveries, even these made as lately as 25 years in the past, have been met with rejection; no longer skepticism or wary restraint, yet outright rejection. in the course of the 60's, there has been a gentle attractiveness of the organization among viruses and melanoma, the results of landmark stories in experimental platforms, and this ended in a frenzy of task within the box. There one other interval of doubt and uncertainty, as a result hassle in trying to practice without delay, and looking back inappropriately, the tenets of infectious sickness to human cancers, in basic terms to have the sector resurrected, revitalized and redirected by means of the explosion of growth in molecular biology and genetics.

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Extra info for RNA Tumor Viruses, Oncogenes, Human Cancer and AIDS: On the Frontiers of Understanding: Proceedings of the International Conference on RNA Tumor Viruses in Human Cancer, Denver, Colorado, June 10–14, 1984

Example text

Ellis RW, Lowy DR, Scolnick EM: The viral and cellular ras gene family. In Klein G (ed) Oncogene Studies, Advances in Viral Oncology~Vol. 1), Raven Press, New York, 1982, pp 107-126. 2. Chang EH, Gonda MA, Ellis RW, Scolnick EM, Lowy DR: Human genome contains four genes homologous to transforming genes of Harvey and Kirsten murine sarcoma viruses. Proc Natl Acad Sci USA (79): 4848-4852, 1982. 3. Dhar R, Ellis RW, Shih TY, Oroszlan S, Shapiro B, Maizel J, Lowy 0, Scolnick EM: Nucleotide sequence of the p21 transforming protein of Harvey murine sarcoma virus.

Reddy E, Reynolds K, Watson D, Schulz R, Lautenberger J, Papas T: Nucleotide sequence analysis of the proviral genome of avian myelocytomatosis virus (MC29). Proc Natl Acad Sci(80): 2500-2504, 1983. Watson D, Reddy E, Duesberg P, Papas T: Nucleotide sequence analysis of the chicken c-myc gene reveals homologous and unique coding regions by comparison wiith the transforming gene of avian myelocytomatosis virus MC29, ~g-~. Proc Natl Acad Sci(80): 2146-2150, 1983. Watson, D, Psallidopoulos M, Samuel D, Dalla Favera R, Papas T: Nucleotide sequence analysis of human c-myc locus, chicken homologue, and myelocytomatosis virus MC29 transforming gene reveals a highly conserved gen product.

An inappropriate tissue for expression of EGF receptors. can lead to neoplastic transformation. It seems that knowledge of the expression of cellular protooncogenes. in particular the identification of the cell type expressing a particular cell type. is crucial to understanding the mechanism of neopl astic transformation by oncogenes. Additionally. knowledge of the substrates with which oncogenic proteins interact is equally central to unlocking the mechanism involved in cancer. ACKNOWLEDGMENTS We thank C.

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