Rodent Model as Tools in Ethical Biomedical Research by Monica Levy Andersen, Sergio Tufik

By Monica Levy Andersen, Sergio Tufik

​The aim of this e-book is to concisely current details with appreciate to suitable use of experimental rodents in learn. the foundations elaborated search to supply wisdom of the recommendations focused on either administration and clinical study to all who use laboratory animals, with a spotlight at the health and wellbeing and ethics concerning rodents and in addition to improve the notice of the significance of the animal as a examine item and to supply orientation and advice in undertaking laboratory study, schooling or tests.

Show description

Read Online or Download Rodent Model as Tools in Ethical Biomedical Research PDF

Best neuroscience books

Man and Woman: An Inside Story

The saga of intercourse adjustments in mind and behaviour starts with a tiny sperm swimming towards an immense egg, to give a contribution its tiny Y chromosome plus its copies of the opposite chromosomes. Genetic, anatomic and physiologic changes within the male occur, making his mind and behaviour diverse in particular respects from his sister.

Mayo Clinic Medical Neurosciences

Incorporating a robust program to genuine scientific difficulties, this variation of Mayo sanatorium clinical Neurosciences offers some of the most modern and succinct instructing methods to the present prestige of uncomplicated neuroscience wisdom. environment a brand new common for excellence in introductory clinical neuroscience schooling, Benarroch, Daube, Flemming, and Westmoreland use particular skillbuilding tools that facilitate studying via challenge fixing, whereas preserving scholars engaged and targeted NEW TO THE 5th version: A extra centred program TO medical medication reinforces neuroscience techniques and improves retention Skillfully rendered FULL-COLOR illustrations element the center concentration of anatomy and structures in the course of the textual content NEW UPDATES comprise fresh advances in neuroscience, together with neurochemistry and genetics A extra SUCCINCT layout presents today’s scientific scholars a brand new method of studying crucial parts of clinical neuroscience fast and succinctly

The Medical Basis of Psychiatry

Psychiatry has emerged as a burgeoning medical box with significant advances in etiology and remedy of numerous issues. simply as there has been pleasure within the anatomic advances that happened 100 years in the past while Emil Kraepelin and his collaborators took at the huge, immense job of class of psychiatric issues according to rational clinical pondering, new advances in genetics, biochemistry, neuroanatomy and pharmacotherapy of psychological problems have introduced us even toward a greater figuring out of advanced problems like schizophrenia, bipolar ailment, melancholy or even autism.

In Situ Hybridization in Brain

The explosion of curiosity in particular molecules vital for mind functionality and disorder has drawn contributors from various backgrounds towards using in situ hybridization thoughts. research of the mind calls for the anatomic precision and biochemical specificity that this method can very likely carry.

Additional info for Rodent Model as Tools in Ethical Biomedical Research

Example text

Madrid: Instituto de Investigaciones Agrarias/Ministerio da Agricultura, Pesca y Alimentación; 1983. Schmidek WR, Hoshino K, Schmidek M, Timo-Iaria C. Influence of environmental temperature on the sleep-wakefulness cycle in the rat. Physiol Behav. 1972;8:363–71. Sharp PE, La Regina MC. The laboratory rat. Boca Raton: CRC Press; 1998. Chapter 5 Euthanasia Monica Levy Andersen and Vera Baumans According to the International Guiding Principles for Biomedical Research Involving Animals (CIOMS 1985), because of differing legal systems and cultural backgrounds, there are varying approaches to the use of animals for research, testing, and training in different countries.

6 Rat eating food. The feed container should be located in the upper part of the cage. Usually, the fed should not be spread over the floor of the cage because there is the risk of contamination and waste physiological condition, physical activity and environmental temperature. The average daily food and water requirement of an adult rat is between 10–20 g of feed and 20–45 mL of water. Consumption (intake amount + waste) is 25 g and 50 mL, respectively. 2). Pregnancy, nursing, and growth augment these needs.

The presence and production of pheromones is essential for reproduction and staking of territory. Frequent replacement of bedding stresses the animal, resulting in the production of excess pheromones and ammonia. L. Andersen et al. 26 Fig. 2 A cage fitted with a filter. 1 Recommended dimensions of cages holding rats and mice Species Dimensions (cm2) Rat Female with 800 litter In group (cm2) 250–350 Mice Female with 160 litter In group (cm2) 100 Source: Guide for the Care and Use (1996) Minimum height (cm) 18 18 13–15 13–15 of Laboratory Animals replacing the bedding frequently enough brings the concentration of ammonia and other odors above tolerable limits, jeopardizing the study and working conditions for technicians.

Download PDF sample

Rated 4.12 of 5 – based on 32 votes