Rodent Model as Tools in Ethical Biomedical Research by Monica Levy Andersen, Sergio Tufik
By Monica Levy Andersen, Sergio Tufik
The aim of this e-book is to concisely current details with appreciate to suitable use of experimental rodents in learn. the foundations elaborated search to supply wisdom of the recommendations focused on either administration and clinical study to all who use laboratory animals, with a spotlight at the health and wellbeing and ethics concerning rodents and in addition to improve the notice of the significance of the animal as a examine item and to supply orientation and advice in undertaking laboratory study, schooling or tests.
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Additional info for Rodent Model as Tools in Ethical Biomedical Research
Madrid: Instituto de Investigaciones Agrarias/Ministerio da Agricultura, Pesca y Alimentación; 1983. Schmidek WR, Hoshino K, Schmidek M, Timo-Iaria C. Influence of environmental temperature on the sleep-wakefulness cycle in the rat. Physiol Behav. 1972;8:363–71. Sharp PE, La Regina MC. The laboratory rat. Boca Raton: CRC Press; 1998. Chapter 5 Euthanasia Monica Levy Andersen and Vera Baumans According to the International Guiding Principles for Biomedical Research Involving Animals (CIOMS 1985), because of differing legal systems and cultural backgrounds, there are varying approaches to the use of animals for research, testing, and training in different countries.
6 Rat eating food. The feed container should be located in the upper part of the cage. Usually, the fed should not be spread over the floor of the cage because there is the risk of contamination and waste physiological condition, physical activity and environmental temperature. The average daily food and water requirement of an adult rat is between 10–20 g of feed and 20–45 mL of water. Consumption (intake amount + waste) is 25 g and 50 mL, respectively. 2). Pregnancy, nursing, and growth augment these needs.
The presence and production of pheromones is essential for reproduction and staking of territory. Frequent replacement of bedding stresses the animal, resulting in the production of excess pheromones and ammonia. L. Andersen et al. 26 Fig. 2 A cage fitted with a filter. 1 Recommended dimensions of cages holding rats and mice Species Dimensions (cm2) Rat Female with 800 litter In group (cm2) 250–350 Mice Female with 160 litter In group (cm2) 100 Source: Guide for the Care and Use (1996) Minimum height (cm) 18 18 13–15 13–15 of Laboratory Animals replacing the bedding frequently enough brings the concentration of ammonia and other odors above tolerable limits, jeopardizing the study and working conditions for technicians.