The Molecular Biology of Neurological Disease by Roger N. Rosenberg, Juan M. Pascual

By Roger N. Rosenberg, Juan M. Pascual

Overseas specialists evaluate advances within the realizing of the molecular mechanisms of either common and irregular neurological services and their rapid and destiny functions in medical neurology. The 'new genetics' additionally has many functions in different neurological difficulties, together with oncology, urology, improvement, development and differentiation and chemical neurotransmission. Clinicians have to comprehend the foundation of molecular genetics - concepts equivalent to recombiant DNA know-how and genetic linkage experiences. those have rapid scientific relevance, for instance within the improvement of healing items, within the presymptomatic and prenatal detection of genes vendors, so very important in genetic counselling and within the realizing of ailment pathophysiology

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1981) Altered expression of the calcitonin gene associated with RNA polymorphism. Nature, 290, 63-65 ROSENFELD, M . , LIN, C , AMARA, S . , STOLANSKY, L . , ROOS, B . , ONG, E. a n d EVANS, R. ( 1 9 8 2 ) C a l c i t o n i n mRNA polymorphism: peptide switching associated with alternative RNA splicing events. Proceedings of the National Academy of Sciences USA, 79, 1717-1721 ROSENFELD, M . , MERMOD, J . , AMARA, S . , SWENSON, L . , SAWCHENKO, P . , RIVIER, J . , VALE, W. a n d EVANS, R. (1983) Production of a novel neuropeptide encoded by the calcitonin gene with tissue-specific RNA processing.

Tanzi et al. (1987) suggest that in non-familial Alzheimer's disease, variations in the gene encoding ß-amyloid may result in a ß-amyloid protein product that makes the individual susceptible to an environmental factor, the interaction resulting in the disease. VIRUSES AND ALZHEIMER'S DISEASE Slow viruses are likely candidates as possible environmental cofactors in Alzheimer's disease. Viral and genetic aetiologies of Alzheimer's disease are not mutually exclusive (McLachlan and Lewis, 1985). , 1985; Roberts, Crow and Polak, 1985) are at present indistinguishable from those in Alzheimer's disease brain.

Progress in Brain Research, 58, 465-478 CHAUDHARI, N. and HAHN, w. (1983) Genetic expression in the developing brain. Science, 220, 924-929 CHIKARAISHI, D. (1979) Complexity of cytoplasmic polyadenylated and nonpolyadenylated rat brain ribonucleic acids. Biochemistry, 18, 3250-3256 DeCHiARA, τ. and BROSIUS, J. (1987) Neural BC1 RNA: cDNA clones reveal nonrepetitive sequence content. , HELINSKI, D. and DeLUCA, M. (1985) Cloning of firefly luciferase cDNA and the expression of active luciferase in Escherichia coli.

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